Maduramicin Ammonium

Base Information

• Chemical Name: Maduramicin Ammonium
• CAS No.: 84878-61-5
• Deprecated CAS: 106036-03-7,92307-83-0,97375-44-5
• Molecular Formula: C47H79O17.NH4
• Molecular Weight: 934.17
• European Community (EC) Number: 635-502-4
• UNII: 5U912U22T2
• DSSTox Substance ID: DTXSID4048983
• Mol file: 84878-61-5.mol

Synonyms:Maduramicin ammonium;DTXCID0028909;DTXSID4048983;84878-61-5;azanium;2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetate;CAS-84878-61-5;NCGC00185760-01;SCHEMBL433784;Tox21_113443;AKOS040759348;Tox21_113443_1;NCGC00263563-01;ammonium 2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-3'-{[(4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy}-5'-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]-2-methyl-[2,2'-bioxolan]-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetate

Chemical Property of Maduramicin Ammonium

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 173-176oC
• Boiling Point: 938.7 °C at 760 mmHg
• Flash Point: 521.5 °C
• PSA: 211.58000
• LogP: 3.35840
• Storage Temp.: 0-6°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 12
• Exact Mass: 933.56610018
• Heavy Atom Count: 65
• Complexity: 1600

Purity/Quality:

90% ^*data from raw suppliers

Maduramicin ammonium ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 25-27-36
• Safety Statements: 26-28-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C.[NH4+]
• Isomeric SMILES: C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]6[C@@H]([C@H]([C@@H]([C@](O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)OC7C[C@@H]([C@H]([C@@H](O7)C)OC)OC)(C)O)C.[NH4+]
• Description: Maduramycin ammonium salt is a white crystalline powder with a melting point of 165-167°C. It is insoluble in water and soluble in organic solvents. Because of its broad anticoccidial spectrum and not easy to develop drug resistance, it is widely used. The dosage is very small. At present, our country stipulates that the amount of maduramycin ammonium salt added to the feed for preventing chicken coccidiosis is 5mg/kg.
• Uses: Maduramcin ammonium is prepared from maduramicin by taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in ammonium hydroxide solutions. The ammonium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Maduramicin is also active against Treponema and Cryptosporidium. Maduramicin is an ionophore, forming complexes with monovalent cations, with a higher affinity for K+ than Na+. Maduramicin ammonium is prepared from maduramicin by taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in ammonium hydroxide solutions. The ammonium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Maduramicin is also active against Treponema and Cryptosporidium. Maduramicin is an ionophore, forming complexes with monovalent cations, with a higher affinity for K+ than Na+. Polyether antibiotic chemically related to the lonomycins. Coccidiostat