(+-)-Adrenaline hydrochloride

Base Information

• Chemical Name: (+-)-Adrenaline hydrochloride
• CAS No.: 329-63-5
• Molecular Formula: C9H13NO3^.HCl
• Molecular Weight: 219.668
• Hs Code.: 2937901500
• Mol file: 329-63-5.mol

Synonyms:Epinephrine dl- hydrochloride;(+-)-Adrenaline hydrochloride;d-Epinephrine hydrochloride;(1)-4-(1-Hydroxy-2-(methylamino)ethyl)pyrocatechol hydrochloride;Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (+-)-;LS-42885;LS-42886;BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((METHYLAMINO)METHYL)-, HYDROCHLORIDE, (+)-;J-018951;(+/-)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride

Chemical Property of (+-)-Adrenaline hydrochloride

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 157℃
• Boiling Point: 413.1 °C at 760 mmHg
• Flash Point: 207.9 °C
• PSA: 72.72000
• Density: 1.283 g/cm3
• LogP: 1.54350
• Storage Temp.: 2-8°C
• Solubility.: H2O: >50 mg/mL
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 219.0662210
• Heavy Atom Count: 14
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

(+/-)-EpinephrineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 24/25-36/37/38
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[NH2+]CC(C1=CC(=C(C=C1)O)O)O.[Cl-]
• Uses: bronchodilatator, An adrenergic receptor agonist. (±)-Epinephrine hydrochloride has been used:in the induction of renalase expression in Human renal proximal tubular epithelial cellsin the infusion studies to test its effect on heart rate and eye temperature measurements in bullas a medium supplement for the stimulation of endothelial progenitor cells

Technology Process of (+-)-Adrenaline hydrochloride

There total 1 articles about (+-)-Adrenaline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate (87697-27-6) → epinephrine hydrochloride (329-63-5,66240-90-2)

Guidance literature:

With methanol; chloro-trimethyl-silane; for 3h; Reflux;

DOI:10.1055/s-0029-1217027

Reference yield: 71.0%

epinephrine hydrochloride (329-63-5,66240-90-2) + sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate (79060-88-1) → C32H12BF24(1-)*C9H13NO3*H(1+)

Guidance literature:

In methanol; for 12h;

DOI:10.1002/anie.201603821

Reference yield:

epinephrine hydrochloride (329-63-5,66240-90-2) + β‐cyclodextrin (7585-39-9) → C42H70O35*C9H13NO3*ClH

Guidance literature:

In water;

DOI:10.1016/j.cplett.2016.05.031

upstream raw materials:

tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate

Refernces