CID 9817450

Base Information

• Chemical Name: CID 9817450
• CAS No.: 107667-60-7
• Molecular Formula: C9H12N4O3Zn
• Molecular Weight: 289.609
• Metabolomics Workbench ID: 152255
• Mol file: 107667-60-7.mol

Synonyms:

Chemical Property of CID 9817450

Chemical Property:

• Appearance/Colour: White to pale-yellow crystalline solid
• Melting Point: 300 ºC
• Boiling Point: 557.6oC at 760 mmHg
• Flash Point: 291oC
• PSA: 101.31000
• LogP: -0.39430
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Acid (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 288.020082
• Heavy Atom Count: 17
• Complexity: 254

Purity/Quality:

99% ^*data from raw suppliers

Polaprezinc ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C[N-]1)CC(C(=O)[O-])NC(=O)CCN.[Zn+2]
• Isomeric SMILES: C1=C(N=C[N-]1)C[C@@H](C(=O)[O-])NC(=O)CCN.[Zn+2]
• Description: Polaprezinc, a complex of zinc ion and L-carnosine, is an antiulcer agent launched in Japan. It is effective in promoting the healing of gastric ulcers in addition to preventing ulcer relapse. In rat studies, polaprezinc reduces the incidence of stomach lesions induced by ethanol. No effect was seen on ultrastructural damage or on cell proliferation and it appears that polaprezinc combines the cytoprotective effect of zinc with the ulcer healing properties of Lcarnosine. The in vivo antioxidative properties of polaprezinc has been suggested to be responsible for its protective effect against gastric mucosal injury. Recent studies revealed that polaprezinc is an activator of bone formetion and has inhibitory effect of bone resorption. This agent is thus able to prevent the deterioration of bone metabolism indicating its potential usefulness in the treatment of osteoporosis. Polaprezinc has also been claimed for the prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis or other hepatopathies caused by certain drugs, poisons and radiation.
• Uses: A novel anti-gastric ulcer agent PepZinGI(R) is a new dietary supplement approved by the federal agency. Don`t hesitate to contact us for more information. Attributes New dietary supplement Contact anti-ulcer drug, antioxidative,

Technology Process of CID 9817450

There total 2 articles about CID 9817450 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

zinc(II) acetate dihydrate (5970-45-6) + carnosine (305-84-0) → zinc L-carnosine (107667-60-7)

Guidance literature:

With sodium hydroxide; In methanol; at 50 - 60 ℃; for 1h; Temperature;

Reference yield:

Zn(β-alanyl-L-histidine)*DMF (1535206-09-7) → Zn(β-alanyl-L-histidine) (107667-60-7,1535206-08-6)

Guidance literature:

at 130 ℃; for 2h;

DOI:10.1002/anie.201307074

upstream raw materials:

zinc(II) acetate dihydrate

carnosine

Zn(β-alanyl-L-histidine)*DMF

Refernces

• 1、 Katsoulidis, Alexandros P.,Park, Kyo Sung,Antypov, Dmytro,Marti-Gastaldo, Carlos,Miller, Gary J.,Warren, John E.,Robertson, Craig M.,Blanc, Frederic,Darling, George R.,Berry, Neil G.,Purton, John A.,Adams, Dave J.,Rosseinsky, Matthew J.. "Guest-adaptable and water-stable peptide-based porous materials by imidazolate side chain control". supporting information. p. 193 - 198. Retrieved 2014/01/17.