2-(Dimethylamino)ethanol hydrochloride

Base Information

• Chemical Name: 2-(Dimethylamino)ethanol hydrochloride
• CAS No.: 2498-25-1
• Molecular Formula: C4H11 N O . Cl H
• Molecular Weight: 90.1454
• Hs Code.: 2922199090
• European Community (EC) Number: 684-211-9
• UNII: A6A0TB3ES3
• DSSTox Substance ID: DTXSID30179692
• Wikidata: Q27273689
• Mol file: 2498-25-1.mol

Synonyms:2-(diethylamino)ethanol;2-(dimethylamino)ethanol hydrochloride;2-(N,N-dimethylamino)ethanol hydrochloride;2-diethylaminoethanol;2-diethylaminoethanol hydrochloride;2-diethylaminoethanol hydrochloride, 14C-labeled;2-diethylaminoethanol sulfate (2:1);2-diethylaminoethanol tartrate;2-diethylaminoethanol, sodium salt;DEAE;deanol hydrochloride;diethylaminoethanol;diethylethanolamine;ethanol, 2-(dimethylamino)-, hydrochloride (1:1);ethanol, 2-dimethylamino-, hydrochloride;N,N-diethylethanolamine

Chemical Property of 2-(Dimethylamino)ethanol hydrochloride

Chemical Property:

• Vapor Pressure: 3.39mmHg at 25°C
• Boiling Point: 135°Cat760mmHg
• Flash Point: 40.6°C
• PSA: 23.47000
• Density: g/cm³
• LogP: 0.34230
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 125.0607417
• Heavy Atom Count: 7
• Complexity: 28.7

Purity/Quality:

99%, ^*data from raw suppliers

2-(Dimethylamino)ethanolhydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCO.Cl

Technology Process of 2-(Dimethylamino)ethanol hydrochloride

There total 3 articles about 2-(Dimethylamino)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meclofenoxate hydrochloride (3685-84-5) → 4-Chlorophenoxyacetic acid (122-88-3) + 2-(N,N-dimethylamino)ethanol hydrochloride (2498-25-1)

Guidance literature:

With water; at 60 ℃; for 120h; Kinetics; educt as different commercial film coated tablets; var. temp.s, relative humidities, additives and reaction times;

DOI:10.1248/cpb.31.2513

Reference yield:

2-(N,N-dimethylamino)ethanol (108-01-0) + diphenylchloromethane (90-99-3) → diphenhydramine hydrochloride (147-24-0,8052-21-9) + 2-(N,N-dimethylamino)ethanol hydrochloride (2498-25-1)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol; at 175 ℃; for 0.266667h; under 12929 Torr; Overall yield = 71 %Spectr.;

DOI:10.1039/c3sc50859e

Reference yield:

2-(N,N-dimethylamino)ethanol (108-01-0) + 2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone (4359-97-1) → 2-dimethylamino-ethanol; protonated form (2498-25-1) + 2,6-Di-tert-butyl-4-(3,5-di-tert-butyl-4-oxo-cyclohexa-2,5-dienylidenemethyl)-phenol anion (22719-43-3)

Guidance literature:

In acetonitrile; at 25 ℃; under 682.6 Torr; Thermodynamic data; Equilibrium constant; other amines, var. temp., var. pressures; ΔH⁰, ΔS⁰;

DOI:10.1246/bcsj.65.2437

upstream raw materials:

2-(N,N-dimethylamino)ethanol

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone

meclofenoxate hydrochloride

diphenylchloromethane

Downstream raw materials:

(R)-(+)-Cizolirtine

2,5-Bis[3-(N,N-dimethylamino)-1-oxapropyl]-1,4-dibromobenzene

2-(N,N-dimethylamino)ethanol

2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone

Refernces

• 1、 Nishimura, Norio,Iga, Siroh,Satoh, Masahiro,Yamamoto, Shunzo. "Temperature and Pressure Effects on the Reversible Reaction of a Parent Phenol (GH) Corresponding to Galvinoxyl with Aliphatic Amines". . p. 2437 - 2441. Retrieved 2007/10/02.
• 2、 Yoshioka,Shibazaki,Ejima. "Stability of solid dosage forms. II. Hydrolysis of meclofenoxate hydrochloride in commercial tablets". . p. 2513 - 2517. Retrieved 2007/10/02.