3-methoxybenzene-1,2-dicarboxylic acid

Base Information

• Chemical Name: 3-methoxybenzene-1,2-dicarboxylic acid
• CAS No.: 14963-97-4
• Molecular Formula: C9H8O5
• Molecular Weight: 196.16
• Hs Code.: 2918990090
• Mol file: 14963-97-4.mol

Synonyms:Phthalicacid, 3-methoxy- (6CI,8CI);3-Methoxy-1,2-benzenedicarboxylic acid;3-Methoxyphthalic acid;NSC 239374;3-Methoxybenzene-1,2-dicarboxylic acid;

Chemical Property of 3-methoxybenzene-1,2-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 5.66E-07mmHg at 25°C
• Melting Point: 173-174 °C(Solv: water (7732-18-5))
• Refractive Index: 1.59
• Boiling Point: 395.7 °C at 760 mmHg
• PKA: 3.13±0.10(Predicted)
• Flash Point: 163.7 °C
• PSA: 83.83000
• Density: 1.416 g/cm³
• LogP: 1.09160

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-MethoxyphthalicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxyphthalic Acid has metallo-β-lactamase inhibitory activity.

Technology Process of 3-methoxybenzene-1,2-dicarboxylic acid

There total 42 articles about 3-methoxybenzene-1,2-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dimethyl 3-methoxyphthalate (32136-52-0) → 3-methoxyphthalic acid (14963-97-4)

Guidance literature:

With potassium hydroxide; In ethanol; water;

Reference yield: 98.32%

1-methoxy-2-ethyl-3-methylbenzene (6161-63-3) → 3-methoxyphthalic acid (14963-97-4)

Guidance literature:

With potassium permanganate; cetyltrimethylammonim bromide; In water; at 80 - 90 ℃; for 6.5h;

Reference yield: 90.0%

4-methoxyphthalide (4792-33-0) → 3-methoxyphthalic acid (14963-97-4)

Guidance literature:

With potassium hydroxide; potassium permanganate; In water; for 12h; Ambient temperature;

upstream raw materials:

2,3-dimethylanisole

dimethyl 3-methoxyphthalate

(2-carboxy-3-methoxy-phenyl)-glyoxylic acid

3-hydroxyphthalic acid

Downstream raw materials:

diethyl 2-(benzyloxycarbonylamino)-4-methoxyindane-2-phosphonate

2,3-bisbromomethylanisole

(+)-Daunomycinone

2-methoxy-6-methoxycarbonylbenzoic acid

Refernces

• 1、 Miyashita. "-". . . Retrieved 1941.
• 2、 Czopek, Anna,Partyka, Anna,Bucki, Adam,Paw?owski, Maciej,Ko?aczkowski, Marcin,Siwek, Agata,G?uch-Lutwin, Monika,Koczurkiewicz, Paulina,P?kala, El?bieta,Jaromin, Anna,Tyliszczak, Bo?ena,Weso?owska, Anna,Zagórska, Agnieszka. "Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives". . . Retrieved 2020/09/04.
• 3、 -. "Preparation method of 3-hydroxyl phthalic anhydride". Paragraph 0025; 0026. . Retrieved 2017/09/18.