1-(Methoxymethyl)-1H-imidazole

Base Information

• Chemical Name: 1-(Methoxymethyl)-1H-imidazole
• CAS No.: 20075-26-7
• Molecular Formula: C5H8 N2 O
• Molecular Weight: 112.131
• Hs Code.: 2933290090
• European Community (EC) Number: 243-505-3
• UNII: PED3A65HTE
• DSSTox Substance ID: DTXSID90173898
• Nikkaji Number: J280.439E
• Wikidata: Q83043943
• Mol file: 20075-26-7.mol

Synonyms:1-(Methoxymethyl)-1H-imidazole;20075-26-7;1-(methoxymethyl)imidazole;EINECS 243-505-3;PED3A65HTE;1H-Imidazole, 1-(methoxymethyl)-;N-methoxymethyl-imidazole;UNII-PED3A65HTE;1-(methoxymethyl)-imidazole;1-methoxymethyl-1H-imidazole;SCHEMBL425674;DTXSID90173898;N-(METHOXYMETHYL)IMIDAZOLE;AMY20716;MFCD00955700;AKOS014312801;CS-W019016;IMIDAZOLE, 1-(METHOXYMETHYL)-;AS-19257;A4389;FT-0699420;EN300-206295

Chemical Property of 1-(Methoxymethyl)-1H-imidazole

Chemical Property:

• Vapor Pressure: 0.118mmHg at 25°C
• Boiling Point: 227.2°Cat760mmHg
• PKA: 6.53±0.10(Predicted)
• Flash Point: 91.2°C
• PSA: 27.05000
• Density: 1.06g/cm³
• LogP: 0.48700
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 112.063662883
• Heavy Atom Count: 8
• Complexity: 67.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Methoxymethyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCN1C=CN=C1

Technology Process of 1-(Methoxymethyl)-1H-imidazole

There total 3 articles about 1-(Methoxymethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1H-imidazole (288-32-4) + chloromethyl methyl ether (107-30-2) → 1-(methoxymethyl)imidazole (20075-26-7)

Guidance literature:

1H-imidazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

DOI:10.1002/ejoc.201100242

Reference yield: 72.0%

→ 1-(methoxymethyl)imidazole (20075-26-7)

Guidance literature:

Reference yield:

1-(p-methoxybenzoyl)-3-methoxymethylimidazolium chloride (93342-84-8) → 4-methoxy-benzoyl chloride (100-07-2) + 1-(methoxymethyl)imidazole (20075-26-7)

Guidance literature:

In dichloromethane; at 25 ℃; Rate constant; Equilibrium constant;

upstream raw materials:

1H-imidazole

chloromethyl methyl ether

1-(p-methoxybenzoyl)-3-methoxymethylimidazolium chloride

Downstream raw materials:

furan-2-yl-(1-methoxymethyl-1H-imidazol-2-yl)-methanone

1-(p-methoxybenzoyl)-3-methoxymethylimidazolium chloride

3-Methoxymethyl-3H-imidazole-4-carbaldehyde

bis-(4-fluoro-phenyl)-(1-methoxymethyl-1H-imidazol-2-yl)-methanol

Refernces

• 1、 Oikawa, Masato,Ikoma, Minoru,Sasaki, Makoto. "Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate". experimental part. p. 4654 - 4666. Retrieved 2011/10/03.
• 2、 -. "N-HETEROCYCLYL-SUBSTITUTED AMINO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS". Page 121. . Retrieved 2010/02/08.