Donepezil hydrochloride

Base Information

• Chemical Name: Donepezil hydrochloride
• CAS No.: 120011-70-3
• Deprecated CAS: 142057-77-0
• Molecular Formula: C24H30ClNO3
• Molecular Weight: 415.95
• Hs Code.: 2933399090
• European Community (EC) Number: 620-543-2
• NSC Number: 758882,737535
• UNII: 3O2T2PJ89D
• DSSTox Substance ID: DTXSID0046698
• Wikidata: Q27106438
• NCI Thesaurus Code: C2603
• RXCUI: 236559
• Pharos Ligand ID: 32ZAJ8M5AMJT
• ChEMBL ID: CHEMBL1678
• Mol file: 120011-70-3.mol

Synonyms:1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride;Aricept;donepezil;donepezil hydrochloride;donepezilium oxalate trihydrate;E 2020;E-2020;E2020;Eranz

Chemical Property of Donepezil hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white crystalline solid
• Vapor Pressure: 3.11E-11mmHg at 25°C
• Melting Point: 220-222 °C
• Boiling Point: 527.9 °C at 760 mmHg
• Flash Point: 273.1 °C
• PSA: 38.77000
• LogP: 5.10100
• Storage Temp.: -20°C Freezer
• Solubility.: insoluble in EtOH; insoluble in DMSO; ≥10.4 mg/mL in H2O
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 415.1914215
• Heavy Atom Count: 29
• Complexity: 510

Purity/Quality:

99%Min ^*data from raw suppliers

Donepezil hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
• Recent ClinicalTrials: Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture
• Recent EU Clinical Trials: Comparison of therapeutic strategies with Cholinesterase Inhibitors: stop or still (SOS) trial
• Recent NIPH Clinical Trials: A Phase III Study of TK-023 in Patients with Mild to Moderate Dementia of the Alzheimer's Type
• Uses: Donepezil hydrochloride is an inhibitor of acetylcholinesterase with a labelled nootropic. It has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice. It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity. Labeled Donepezil, intended for use as an internal standard for the quantification of Donepezilby GC- or LC-mass spectrometry.
• Therapeutic Function: Anti-Alzheimer's disease
• Clinical Use: Treatment of dementia in mild to moderate Alzheimer’s disease
• Drug interactions: Potentially hazardous interactions with other drugsNone known