6-Methylpyridine-3-carboxylic acid

Base Information

• Chemical Name: 6-Methylpyridine-3-carboxylic acid
• CAS No.: 3222-47-7
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 29333990
• Mol file: 3222-47-7.mol

Synonyms:6-methylpyridine-3-carboxylate;6-methylpyridine-3-carboxylic acid;

Chemical Property of 6-Methylpyridine-3-carboxylic acid

Chemical Property:

• Appearance/Colour: White crystalline
• Vapor Pressure: 0.000659mmHg at 25°C
• Melting Point: 210-213 °C(lit.)
• Refractive Index: 1.5030 (estimate)
• Boiling Point: 296.2 °C at 760 mmHg
• PKA: 2.37±0.10(Predicted)
• Flash Point: 132.9 °C
• PSA: 50.19000
• Density: 1.23 g/cm³
• LogP: 1.08820
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Sparingly soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

6-Methylnicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A degradation product of Nicotinic acid (N429250). An impurity of Nicotinic acid. 6-Methylnicotinic acid is an intermediate of the drug etoricoxib (a non- steroidal anti-inflammatory drug for the treatment of arthritis and osteoarthritis). It is also used as organic intermediates.

Technology Process of 6-Methylpyridine-3-carboxylic acid

There total 17 articles about 6-Methylpyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl 6-methylnicotinate (5470-70-2) → 6-methylnicotinic acid (3222-47-7)

Guidance literature:

Reference yield: 84.2%

2-methyl-5-vinylpyridine (140-76-1,25038-86-2) → 6-methylnicotinic acid (3222-47-7)

Guidance literature:

With potassium permanganate; In water; at 80 ℃; for 0.05h;

DOI:10.1007/BF00767669

Reference yield: 75.4%

1-(6-methyl-pyridin-3-yl)-ethanone (36357-38-7) → 6-methylnicotinic acid (3222-47-7)

Guidance literature:

With nitric acid; for 5h; Heating;

upstream raw materials:

5-ethyl-2-methyl-pyridine

1-(6-methyl-pyridin-3-yl)-ethanone

6-methylnicotinonitrile

ethyl 6-methylnicotinate

Downstream raw materials:

6-trans-styryl-nicotinic acid

6-methyl-thionicotinic acid S-phenyl ester

dimethyl 2,5-pyridine dicarboxylate

6-trichloromethyl-nicotinic acid methyl ester

Refernces

• 1、 -. "2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL". Paragraph 0625. . Retrieved 2017/07/14.
• 2、 -. "Protease inhibitors". . . Retrieved 2008/06/13.