TICARCILLIN DISODIUM SALT

Base Information

• Chemical Name: TICARCILLIN DISODIUM SALT
• CAS No.: 29457-07-6
• Molecular Formula: C15H16 N2 O6 S2 . 2 Na
• Molecular Weight: 428.397
• Mol file: 29457-07-6.mol

Synonyms:3-Thiophenemalonamicacid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-,disodium salt, D-(-)- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-, disodium salt,[2S-[2a,5a,6b(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-, disodium salt,(2S,5R,6R)- (9CI);6-D(-)-(a-Carboxy-3-thienylacetamido)penicillanic acid disodium salt;6-D-(-)-a-Carboxy-3-thienylmethylacetamidopenicillanic acid;AB 2288;BRL 2288;Disodium ticarcillin;Monapen;Ticar;Ticarcillin disodium;Ticarcillin disodium salt;Ticarcillin sodium;Ticarcillin sodium salt;Ticarpen;a-Carboxy-3-thienylmethylpenicillin disodium salt;

Chemical Property of TICARCILLIN DISODIUM SALT

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 7.97E-25mmHg at 25°C
• Boiling Point: 768.3oC at 760 mmHg
• Flash Point: 418.4oC
• PSA: 183.21000
• LogP: -1.79260

Purity/Quality:

80%min, ^*data from raw suppliers

Timentin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: TICARCILLIN DISODIUM SALT, a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.

Technology Process of TICARCILLIN DISODIUM SALT

There total 3 articles about TICARCILLIN DISODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ticarcillin → ticarcillin disodium (29457-07-6)

Guidance literature:

With sodium 2-ethylhexanoic acid; In methanol; water; ethyl acetate; at 20 - 30 ℃; for 3h; Time;

Reference yield:

2-(thiophen-3-yl)malonic acid (21080-92-2) → ticarcillin disodium (29457-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / -5 - 0 °C

2: dichloromethane / 2 h / -5 - 0 °C

3: sodium 2-ethylhexanoic acid / ethyl acetate; water; methanol / 3 h / 20 - 30 °C

With triethylamine; sodium 2-ethylhexanoic acid; In methanol; dichloromethane; water; ethyl acetate;

Reference yield:

6-Aminopenicillanic Acid (551-16-6) → ticarcillin disodium (29457-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 30 - 40 °C

2: dichloromethane / 2 h / -5 - 0 °C

3: sodium 2-ethylhexanoic acid / ethyl acetate; water; methanol / 3 h / 20 - 30 °C

With sodium 2-ethylhexanoic acid; In methanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

2-(thiophen-3-yl)malonic acid

6-Aminopenicillanic Acid

Downstream raw materials:

benzyl 6β-penicillanate

Refernces