Propoxyphene hydrochloride

Base Information

• Chemical Name: Propoxyphene hydrochloride
• CAS No.: 1639-60-7
• Deprecated CAS: 25312-78-1,62-69-1,6414-50-2,6585-54-2,56533-07-4,56533-07-4,62-69-1,6414-50-2,6585-54-2
• Molecular Formula: C22H30ClNO2
• Molecular Weight: 375.939
• European Community (EC) Number: 216-683-5
• UNII: CB2TL9PS0T
• DSSTox Substance ID: DTXSID6048913
• Wikidata: Q27108093
• NCI Thesaurus Code: C29385
• Pharos Ligand ID: VYH4RZ1YFVNF
• ChEMBL ID: CHEMBL1237104
• Mol file: 1639-60-7.mol

Synonyms:D Propoxyphene;D-Propoxyphene;Darvon;Dextropropoxyphene;Hydrochloride, Propoxyphene;Propoxyphene;Propoxyphene Hydrochloride;Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer;Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer;Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer;Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer;Propoxyphene Maleate, (+)-Isomer;Propoxyphene Phosphate, (S-(R*,S*))-Isomer;Propoxyphene Sulfate, (S-(R*,S*))-Isomer

Chemical Property of Propoxyphene hydrochloride

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: 165-1670C
• Boiling Point: 444 °C at 760 mmHg
• Flash Point: 130.6 °C
• PSA: 29.54000
• LogP: 5.07750
• Storage Temp.: -20°C Freezer
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent).
• Water Solubility.: 3.7mg/L(25 oC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 375.1965069
• Heavy Atom Count: 26
• Complexity: 397

Purity/Quality:

98%,99%, ^*data from raw suppliers

(+)-Propoxyphene (hydrochloride) (CRM) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C.Cl
• Isomeric SMILES: CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C.Cl
• Recent ClinicalTrials: Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain
• Uses: Dextropropoxyphene is a controlled substance (opiate). Analgesic (narcotic). The α-dl-and d-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Dextropropoxyphene is a controlled substance (narcotic)

Technology Process of Propoxyphene hydrochloride

There total 1 articles about Propoxyphene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ propoxyphene hydrochloride (1639-60-7)

Guidance literature:

Zusammenfassende Darstellung;

Reference yield: 96.3%

propoxyphene hydrochloride (1639-60-7) + cataflam (15307-86-5,15307-81-0) → (2S,3R)-(+)-4-(dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate diclofenate

Guidance literature:

In water; at 50 ℃; for 0.25 - 0.5h; Product distribution / selectivity;

Reference yield: 76.3%

diclofenac sodium (15307-79-6) + propoxyphene hydrochloride (1639-60-7) → (2S,3R)-(+)-4-(dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate diclofenate

Guidance literature:

In water; at 50 ℃; Product distribution / selectivity;

Downstream raw materials:

(E)-1,2-diphenyl-2-butene

Z-1,2-diphenyl-2-butene

cis-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾

trans-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾