2,3,5,6-tetramethylbenzonitrile

Base Information

• Chemical Name: 2,3,5,6-tetramethylbenzonitrile
• CAS No.: 2571-53-1
• Molecular Formula: C11H13 N
• Molecular Weight: 159.231
• Mol file: 2571-53-1.mol

Synonyms:2,3,5,6-Tetramethylbenzonitrile;Cyanodurene; NSC 409548

Chemical Property of 2,3,5,6-tetramethylbenzonitrile

Chemical Property:

• Vapor Pressure: 0.00206mmHg at 25°C
• Boiling Point: 290.6°Cat760mmHg
• Flash Point: 129.9°C
• Density: 0.96g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5,6-tetramethylbenzonitrile

There total 9 articles about 2,3,5,6-tetramethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Dichloromethyl methyl ether (4885-02-3) + 1,2,4,5-tetramethylbenzene (95-93-2) → 2,3,5,6-tetramethylbenzonitrile (2571-53-1)

Guidance literature:

Dichloromethyl methyl ether; 1,2,4,5-tetramethylbenzene; With zinc dibromide; In dichloromethane; at 20 ℃; for 14h;

With ammonium hydroxide; iodine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1002/ejoc.201403672

Reference yield: 68.0%

2,3,5,6-tetramethylbenzoic acid (2604-45-7) → 2,3,5,6-tetramethylbenzonitrile (2571-53-1)

Guidance literature:

With lead(II) thiocyanate; at 200 - 230 ℃;

Reference yield: 38.0%

2,3,5,6-tetramethylbenzene-1,4-dicarbonitrile (2619-37-6) → 2,3,5,6-tetramethylbenzonitrile (2571-53-1)

Guidance literature:

With triethylamine; In acetonitrile; for 6h; Irradiation;

DOI:10.1246/cl.1986.361

upstream raw materials:

2,3,5,6-tetramethyl-benzoic acid amide

ethylene glycol

2,3,5,6-tetramethylbenzene-1,4-dicarbonitrile

2,3,5,6-tetramethylbenzoic acid

Downstream raw materials:

diduryldiazomethane

Didurylcarben

bis(2,3,5,6-tetramethylphenyl)methanone

Refernces

• 1、 Rudenko,Salfetnikova,Vasil'ev. "Oxidation of Aromatic Compounds. V. Oxidation of Substituted Benzonitriles and 2,4,6-Triaryl-1,3,5-Triazines in System HSO3F-PbO2". . p. 1447 - 1470. Retrieved 2007/10/03.
• 2、 Rudenko, A. P.,Cheremisin, A. A.,Shchegoleva, L. N.,Detsina, A. N.,Zarubin, M. Ya.. "RADICAL-CATIONS OF METHYL-SUBSTITUTED BENZONITRILES". . p. 1675 - 1684. Retrieved 2007/10/02.