Acepromazine maleate

Base Information

• Chemical Name: Acepromazine maleate
• CAS No.: 3598-37-6
• Deprecated CAS: 2664-15-5
• Molecular Formula: C19H22N2OS•C4H4O4
• Molecular Weight: 442.53
• Hs Code.: 2934302300
• European Community (EC) Number: 222-748-9
• NSC Number: 760058
• UNII: 37862HP2OM
• DSSTox Substance ID: DTXSID6047783
• NCI Thesaurus Code: C76652
• RXCUI: 1114057
• ChEMBL ID: CHEMBL1883146
• Mol file: 3598-37-6.mol

Synonyms:Acepromazine;Acepromazine Maleate;Acetazine;Acetopromazine;Acetylpromazine;Calmivet;Maleate, Acepromazine;Plegicil;Vetranquil

Chemical Property of Acepromazine maleate

Chemical Property:

• Appearance/Colour: Yellow crystalline solid
• Melting Point: 135-136 °C
• Boiling Point: 497oC at 760 mmHg
• PKA: 9.3(at 25℃)
• Flash Point: 254.4oC
• PSA: 123.45000
• Density: 1.155g/cm3
• LogP: 4.22040
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: >10mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 442.15624311
• Heavy Atom Count: 31
• Complexity: 533

Purity/Quality:

98%,99%, ^*data from raw suppliers

Acepromazine maleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N,T
• Statements: 22-50/53-20/21/22-43-36/37/38-23/24/25
• Safety Statements: 60-61-36/37/39-26-22-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=C\C(=O)O)\C(=O)O
• Description: Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine , and a dopamine receptor antagonist. It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (; IC50 = 840 nM). Acepromazine inhibits morphine-induced vomiting in dogs. It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively). Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.
• Uses: A tranquilizer antihistamine vitamin D2 analog, blood calcium regulator, therapeutc for chronic hypocalcemia Acepromazine maleate has been used:as a component of anesthesia cocktail to test its effects on behavioral changes in ratsas a component of anesthesia cocktail to study its effects on lung resistance of ratsas an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells
• Therapeutic Function: Neuroleptic, Antiemetic