Nizofenone

Base Information

• Chemical Name: Nizofenone
• CAS No.: 54533-85-6
• Molecular Formula: C₂₁H₂₁ClN₄O₃
• Molecular Weight: 412.876
• Hs Code.: 2933290090
• UNII: 7A2NOC3R88
• DSSTox Substance ID: DTXSID401014745
• Nikkaji Number: J11.942C
• Wikipedia: Nizofenone
• Wikidata: Q15409362
• NCI Thesaurus Code: C76783
• Metabolomics Workbench ID: 154343
• ChEMBL ID: CHEMBL2106822
• Mol file: 54533-85-6.mol

Synonyms:1-(2-(2-chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole;Midafenone;nizofenone;nizofenone fumarate;Y-1979;Y-9179

Chemical Property of Nizofenone

Chemical Property:

• Vapor Pressure: 8.3E-15mmHg at 25°C
• Melting Point: 75-76°
• Refractive Index: 1.623
• Boiling Point: 609.7 °C at 760 mmHg
• PKA: 8.75±0.25(Predicted)
• Flash Point: 322.5 °C
• PSA: 83.95000
• Density: 1.28 g/cm³
• LogP: 5.02990
• Storage Temp.: 2-8°C
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 412.1302182
• Heavy Atom Count: 29
• Complexity: 569

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nizofenone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC1=NC=CN1C2=C(C=C(C=C2)[N+](=O)[O-])C(=O)C3=CC=CC=C3Cl
• Description: Nizofenzone fumarate is a potent antianoxic agent reported of benefit to geriatric and stroke patients. In animal models nizofenzone is reported to have protective effects against anoxia, global ischemia or other conditions resulting from cerebral infarction. It is also claimed to be a sedative and anticonvulsant.

Technology Process of Nizofenone

There total 1 articles about Nizofenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ nizofenone (54533-85-6)

Guidance literature:

2,2'-Dichlor-5-nitrobenzophenon, entspr. Imidazol (hergestellt aus entspr. 2-Hydroxymethyl-imidazol, 1.) SOCl2, 2.) Et2NH (Bsp. 1, S.13));