TETRAHYDROPALMATINE HYDROCHLORIDE

Base Information

• Chemical Name: TETRAHYDROPALMATINE HYDROCHLORIDE
• CAS No.: 6024-85-7
• Molecular Formula: C₂₁H₂₅NO₄*ClH
• Molecular Weight: 391.895
• NSC Number: 209411,132058,132057
• UNII: 4AA8F911N9
• Wikidata: Q27259340
• ChEMBL ID: CHEMBL1412574
• Mol file: 6024-85-7.mol

Synonyms:6H-Dibenzo[a,g]quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, hydrochloride (9CI);6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-,hydrochloride, (?à)-;Berbine, 2,3,9,10-tetramethoxy-, hydrochloride, (?à)- (8CI); (?à)-Tetrahydropalmatine hydrochloride; NSC 132057; NSC209411; Tetrahydropalmatine hydrochloride; dl-Tetrahydropalmatine hydrochloride

Chemical Property of TETRAHYDROPALMATINE HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 1.76E-09mmHg at 25°C
• Melting Point: 250-252ºC
• Boiling Point: 482.9 °C at 760 mmHg
• Flash Point: 138.7 °C
• PSA: 40.16000
• LogP: 4.11640
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 391.1550360
• Heavy Atom Count: 27
• Complexity: 475

Purity/Quality:

DL-TetrahydropalmatineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC.Cl
• Uses: Hydrochloride salt of DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats through the antagonism of striatal dopamine D2 receptor.

Technology Process of TETRAHYDROPALMATINE HYDROCHLORIDE

There total 1 articles about TETRAHYDROPALMATINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydropalmatine (483-14-7,2934-97-6,3520-14-7,10097-84-4,84-38-8) → 2,3,9,10-tetramethoxy-13aα-berbine; hydrochloride (2506-20-9,4880-82-4,6024-83-5,6024-85-7)

Guidance literature:

With hydrogenchloride; In methanol; water;

DOI:10.1055/s-0031-1280126

upstream raw materials:

tetrahydropalmatine

Refernces