3-CHLORO-6-PHENYL-4-PYRIDAZINECARBONITRILE

Base Information

• Chemical Name: 3-CHLORO-6-PHENYL-4-PYRIDAZINECARBONITRILE
• CAS No.: 94011-64-0
• Molecular Formula: C11H6ClN3
• Molecular Weight: 215.642
• Hs Code.: 2933998090
• Mol file: 94011-64-0.mol

Synonyms:3-chloro-6-phenyl-pyridazine-4-carbonitrile;3-Chloro-4-cyano-6-phenylpyridazine;

Chemical Property of 3-CHLORO-6-PHENYL-4-PYRIDAZINECARBONITRILE

Chemical Property:

• Melting Point: 206 °C (propan-2-ol)
• PSA: 49.57000
• LogP: 2.66868

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6-phenyl-pyridazine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-6-PHENYL-4-PYRIDAZINECARBONITRILE

There total 4 articles about 3-CHLORO-6-PHENYL-4-PYRIDAZINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxamide (87769-56-0) → 3-chloro-6-phenylpyridazine-4-carbonitrile (94011-64-0)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

DOI:10.1016/S0960-894X(03)00134-3

Reference yield:

ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate (94011-50-4) → 3-chloro-6-phenylpyridazine-4-carbonitrile (94011-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / bromine / acetic acid

2: 86 percent / conc. aq. NH₃ / 20 °C

3: 60 percent / POCl₃ / 3 h / 80 - 90 °C

With ammonium hydroxide; bromine; trichlorophosphate; In acetic acid;

DOI:10.1021/jm00123a004

Reference yield:

diethyl phenacylmalonate (94011-49-1) → 3-chloro-6-phenylpyridazine-4-carbonitrile (94011-64-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / hydrazine hydrate / ethanol / Ambient temperature

2: 60 percent / bromine / acetic acid

3: 86 percent / conc. aq. NH₃ / 20 °C

4: 60 percent / POCl₃ / 3 h / 80 - 90 °C

With ammonium hydroxide; bromine; hydrazine hydrate; trichlorophosphate; In ethanol; acetic acid;

DOI:10.1021/jm00123a004

upstream raw materials:

2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxamide

ethyl 2,3-dihydro-3-oxo-6-phenyl-4-pyridazinecarboxylate

ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate

diethyl phenacylmalonate

Downstream raw materials:

3-(2-morpholinoethylamino)-4-cyano-6-phenylpyridazine dihydrochloride

5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Refernces

• 1、 Wermuth,Schlewer,Bourguignon,Maghioros,Bouchet,Moire,Kan,Worms,Biziere. "3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities". . p. 528 - 537. Retrieved 2007/10/02.