ethyl 1H-pyrazole-5(3)-carboxylate

Base Information

• Chemical Name: ethyl 1H-pyrazole-5(3)-carboxylate
• CAS No.: 21056-77-9
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.142
• Mol file: 21056-77-9.mol

Synonyms:2H-Pyrazole-3,4-dicarboxylic acid diethyl ester;3-Carbethoxypyrazole;1H-Pyrazol-5-carbonitril;Pyrazol-5-carbonsaeure-aethylester;ethyl 1H-pyrazole-5-carboxylate;5-Ethoxycarbonyl-pyrazol;1H-Pyrazole-3,4-dicarboxylic acid,diethyl ester;cyano-5 pyrazole;2H-pyrazole-3-carboxylic acid ethyl ester;diethyl 2H-pyrazole-3,4-dicarboxylate;

Chemical Property of ethyl 1H-pyrazole-5(3)-carboxylate

Chemical Property:

• PSA: 54.98000
• LogP: 0.58640

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-1H-PYRAZOLE-5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1H-pyrazole-5(3)-carboxylate

There total 7 articles about ethyl 1H-pyrazole-5(3)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (E)-4-(dimethylamino)-2-oxo-but-3-enoate (181427-25-8) → 2H-pyrazole-3-carboxylic acid ethyl ester (21056-77-9)

Guidance literature:

With hydrazine hydro-chloride; In methanol; at 60 ℃; for 6h;

DOI:10.1080/14756366.2018.1512596

Reference yield: 80.0%

ethanol (64-17-5) + (3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one (59938-07-7) → 2H-pyrazole-3-carboxylic acid ethyl ester (21056-77-9)

Guidance literature:

With hydrazine hydrochloride; for 4h; Heating;

DOI:10.1055/s-1995-4147

Reference yield: 68.0%

ethanol (64-17-5) + 1H-pyrazole-3-carboxylic acid (1621-91-6,797027-83-9) → 2H-pyrazole-3-carboxylic acid ethyl ester (21056-77-9)

Guidance literature:

With sulfuric acid; for 14h; Reflux;

upstream raw materials:

ethanol

(3E)-1,1,1-trichloro-4-ethoxybut-3-en-2-one

ethyl (E)-4-(dimethylamino)-2-oxo-but-3-enoate

2-oxo-propionic acid ethyl ester

Downstream raw materials:

ethyl 1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

4-iodo-2H-pyrazole-3-carboxylic acid ethyl ester

ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid

Refernces

• 1、 -. "JNK inhibitor as well as pharmaceutical composition and application thereof". Paragraph 0556-0559. . Retrieved 2021/03/31.
• 2、 Magalh?es, Joana,Franko, Nina,Annunziato, Giannamaria,Welch, Martin,Dolan, Stephen K.,Bruno, Agostino,Mozzarelli, Andrea,Armao, Stefano,Jirgensons, Aigars,Pieroni, Marco,Costantino, Gabriele,Campanini, Barbara. "Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design". . p. 1444 - 1452. Retrieved 2018/09/25.