yclobutanebutanaMide, .beta.-aMino-.alpha.-oxo-, hydrochloride (1:1)

Base Information

• Chemical Name: yclobutanebutanaMide, .beta.-aMino-.alpha.-oxo-, hydrochloride (1:1)
• CAS No.: 817169-86-1
• Molecular Formula: C8H15ClN2O2
• Molecular Weight: 206.672
• Hs Code.: 2924299090
• Mol file: 817169-86-1.mol

Synonyms:Cyclobutanebutanamide, .beta.-amino-.alpha.-oxo-, monohydrochloride (9CI); 3-Amino-4-cyclobutyl-2-oxobutanamide hydrochloride;

Chemical Property of yclobutanebutanaMide, .beta.-aMino-.alpha.-oxo-, hydrochloride (1:1)

Chemical Property:

• PSA: 86.18000
• LogP: 1.76090
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

β-Amino-α-oxo-cyclobutanebutanamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: β-AMino-α-oxo-cyclobutanebutanaMide Hydrochloride is an intermediate used for the synthetic preparation of Boceprevir (B674500), an nonstructural protein 3 (NS3) serine protease inhibitor of hepatitis C virus. β-Am ino-α-oxo-cyclobutanebutanamide is utilized for the treatment of HCV infection.

Technology Process of yclobutanebutanaMide, .beta.-aMino-.alpha.-oxo-, hydrochloride (1:1)

There total 1 articles about yclobutanebutanaMide, .beta.-aMino-.alpha.-oxo-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C13H22N2O4 (817169-85-0) → C8H14N2O2*ClH (817169-86-1)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 40 - 50 ℃; for 4h;

Reference yield: 90.0%

(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (816444-90-3) + C8H14N2O2*ClH (817169-86-1) → boceprevir (394730-60-0) + N-methylmorpholine hydrochloride (3651-67-0)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at 0 - 10 ℃; for 1h;

Reference yield: 85.0%

(1R,2S,5S)-3-((S)-2-(3-tert-butylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (816444-90-3) + C8H14N2O2*ClH (817169-86-1) → boceprevir (394730-60-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 15 - 20 ℃; for 1h;

upstream raw materials:

C₁₃H₂₂N₂O₄

Downstream raw materials:

boceprevir

N-methylmorpholine hydrochloride

(1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-(((S)-3,3-dimethyl-2-(3-trifluoromethyl)phenylamino)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

Refernces