N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

Base Information

• Chemical Name: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine
• CAS No.: 179552-75-1
• Molecular Formula: C15 H12 Cl F N4 O
• Molecular Weight: 318.738
• Mol file: 179552-75-1.mol

Synonyms:Dacomitinib Impurity 1;7-Methoxy-N4-(3-chloro-4-fluorophenyl)-4,6-quinazolinediamine;N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine;4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-methoxy-;N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

Chemical Property of N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

Chemical Property:

• Boiling Point: 487.3±45.0 °C(Predicted)
• PKA: 6.03±0.30(Predicted)
• PSA: 0.00000
• Density: 1.458±0.06 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N4-(3-Chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

There total 15 articles about N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin- 4-amine (179552-74-0) → N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (179552-75-1)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran;

Reference yield: 94.0%

→ N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (179552-75-1)

Guidance literature:

With hydrogen; In tetrahydrofuran; for 48h;

Reference yield: 69.0%

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride (1012057-48-5) → N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (179552-75-1)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 1h; Heating / reflux;

upstream raw materials:

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin- 4-amine

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

7-fluoro-6-nitro-3H-quinazolin-4-one

Downstream raw materials:

methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)butanoate

C₁₅H₁₀ClFIN₃O

Methyl 3-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)propanoate

methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate

Refernces

• 1、 -. "Preparation method of dacotinib". Paragraph 0047-0057. . Retrieved 2022/01/10.
• 2、 -. "Tyrosine kinase inhibitor and pharmaceutical application thereof". Paragraph 0019; 0021; 0028-0029. . Retrieved 2021/08/19.