Ethanone, 1-(5-methyl-3-pyridinyl)-

Base Information

• Chemical Name: Ethanone, 1-(5-methyl-3-pyridinyl)-
• CAS No.: 42972-46-3
• Molecular Formula: C8H9NO
• Molecular Weight: 135.166
• Hs Code.: 2933399090
• Mol file: 42972-46-3.mol

Synonyms:Ethanone, 1-(5-Methyl-3-pyridinyl)-;3 - acetyl - 5 - Methylpyridine

Chemical Property of Ethanone, 1-(5-methyl-3-pyridinyl)-

Chemical Property:

• Boiling Point: 250.5±20.0 °C(Predicted)
• PKA: 3.72±0.20(Predicted)
• PSA: 29.96000
• Density: 1.036±0.06 g/cm3(Predicted)
• LogP: 1.59260
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(5-Methylpyridin-3-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(5-methyl-3-pyridinyl)-

There total 6 articles about Ethanone, 1-(5-methyl-3-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-methoxy-N,5-dimethylnicotinamide (342602-12-4) + methyl magnesium (1+); bromide → 1-(5-methylpyridin-3-yl)ethanone (42972-46-3)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 6h;

Reference yield: 30.0%

5-cyano-3-methylpyridine (42885-14-3) + methylmagnesium bromide (75-16-1) → 1-(5-methylpyridin-3-yl)ethanone (42972-46-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 2h; Heating / reflux;

Reference yield:

5-bromo-3-picoline (3430-16-8) → 1-(5-methylpyridin-3-yl)ethanone (42972-46-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tributyl(1-ethoxyvinyl)stannane; potassium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 1h; Microwave irradiation;

upstream raw materials:

N-methoxy-N,5-dimethylnicotinamide

5-cyano-3-methylpyridine

methylmagnesium bromide

5-bromo-3-picoline

Downstream raw materials:

5-methyl-1-(3,5-di-O-benzoyl-α-D-ribofuranosyl)-3-methoxycarbonylpyridinium chloride

5-methyl-1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-3-methoxycarbonylpyridinium chloride

5-methylnicotinic acid methyl ester

3-Acetyl-1-((2S,3R,4R,5R)-3,4-bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-yl)-5-methyl-pyridinium; bromide

Refernces

• 1、 -. "ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 38. . Retrieved 2013/05/21.
• 2、 -. "COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS". Page/Page column 31-32. . Retrieved 2009/01/20.