N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide

Base Information

• Chemical Name: N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
• CAS No.: 1005450-55-4
• Molecular Formula: C22H20F3NO
• Molecular Weight: 371.402
• Hs Code.: 2924299090
• Mol file: 1005450-55-4.mol

Synonyms:N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide

Chemical Property of N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide

Chemical Property:

• Melting Point: 90-92℃ (cyclohexane )
• Boiling Point: 530.5±50.0 °C(Predicted)
• PKA: 15.18±0.46(Predicted)
• PSA: 29.10000
• Density: 1.210±0.06 g/cm3(Predicted)
• LogP: 6.05950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide

There total 25 articles about N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(3-trifluoromethyl-phenyl)-propynoic acid ((R)-1-naphthalen-1-yl-ethyl)-amide (1095393-72-8) → (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide (1005450-55-4,955371-05-8)

Guidance literature:

With hydrogen; palladium on activated carbon; In methanol; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 96.0%

(R)-1-(1-Naphthyl)ethylamine (3886-70-2) + 2,2-dimethyl-5-(3-(trifluoromethyl)benzyl)-1,3-dioxane-4,6-dione → (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide (1005450-55-4,955371-05-8)

Guidance literature:

In toluene; for 12h; Solvent; Reflux;

Reference yield: 95.0%

3-(3-trifluoromethylphenyl)propanoic acid (585-50-2) + (R)-<1-(1-Naphthyl)ethyl>ammonium chloride (82572-04-1) → (R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide (1005450-55-4,955371-05-8)

Guidance literature:

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride; With sodium hydroxide; In toluene;

3-(3-trifluoromethylphenyl)propanoic acid; In toluene; at 140 - 150 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.11.030

upstream raw materials:

(R)-1-(1-Naphthyl)ethylamine

3-(trifluoromethyl)benzenepropanoic acid chloride

3-(3-trifluoromethylphenyl)propanoic acid

(R)-<1-(1-Naphthyl)ethyl>ammonium chloride

Downstream raw materials:

cinacalcet

cinacalcet hydrochloride

[3-(3-difluoromethyl-phenyl)-propyl]-((R)-1-naphthalen-1-yl-ethyl)-amine

Refernces

• 1、 Sun, Xiao,Wang, Xueyang,Liu, Feipeng,Gao, Zidong,Bian, Qinghua,Wang, Min,Zhong, Jiangchun. "Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling". . p. 682 - 687. Retrieved 2019.
• 2、 -. "Preparation method of cinacalcet hydrochloride". Paragraph 0036; 0038; 0040; 0043-0047. . Retrieved 2020/10/05.
• 3、 -. "Synthesis method of cinacalcet hydrochloride intermediate". Paragraph 0061-0068. . Retrieved 2020/05/01.