LY-2484595

Base Information

• Chemical Name: LY-2484595
• CAS No.: 1186486-62-3
• Molecular Formula: C31H36F6N6O2
• Molecular Weight: 638.656
• Mol file: 1186486-62-3.mol

Synonyms:LY2484595; trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid; LY-2484595

Chemical Property of LY-2484595

Chemical Property:

• Boiling Point: 680.1±65.0 °C(Predicted)
• PKA: 4.73±0.10(Predicted)
• PSA: 87.38000
• Density: 1.40
• LogP: 7.16860
• Solubility.: ≥32.1 mg/mL in DMSO; insoluble in H2O; ≥50.4 mg/mL in EtOH with ultrasonic

Purity/Quality:

98%,99%, ^*data from raw suppliers

Evacetrapib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Evacetrapib is an inhibitor of?cholesteryl ester transfer protein (CETP). CETP catalyzes the exchange of cholesteryl ester and triglyceride between lipoproteins and modulates HDL cholesterol levels in plasma. CETP inhibitors are potential compounds for treating coronary artery disease.

Technology Process of LY-2484595

There total 1 articles about LY-2484595 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H38F6N6O2 → Evacetrapib (1186486-62-3) + C31H36F6N6O2 (1587704-15-1)

Guidance literature:

With water; sodium hydroxide; In isopropyl alcohol; at 60 ℃; for 7h; Overall yield = 92 %;

DOI:10.1021/op500025v

Refernces