IOX2

Base Information

• Chemical Name: IOX2
• CAS No.: 931398-72-0
• Molecular Formula: C₁₉H₁₆N₂O₅
• Molecular Weight: 352.346
• Mol file: 931398-72-0.mol

Synonyms:N-[(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]glycine; IOX2

Chemical Property of IOX2

Chemical Property:

• Boiling Point: 642.8±55.0 °C(Predicted)
• PKA: 3.61±0.10(Predicted)
• PSA: 108.63000
• Density: 1.470±0.06 g/cm3(Predicted)
• LogP: 1.96070
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

99% ^*data from raw suppliers

IOX 2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM. IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

Technology Process of IOX2

There total 2 articles about IOX2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium glycinate (6000-44-8) + ethyl 4-hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinecarboxylate (130058-54-7) → N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine (931398-72-0)

Guidance literature:

sodium glycinate; ethyl 4-hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinecarboxylate; In ethanol; at 150 - 200 ℃; for 0.116667h; Microwave;

With hydrogenchloride; In ethanol; water; Product distribution / selectivity;

Reference yield:

→ N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine (931398-72-0)

Guidance literature:

upstream raw materials:

sodium glycinate

ethyl 4-hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinecarboxylate

Refernces