Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate

Base Information Edit

Chemical Name:Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate
CAS No.:136304-78-4
Molecular Formula:C22H19N3O2
Molecular Weight:357.412
Hs Code.:2926909090
DSSTox Substance ID:DTXSID60576392
Nikkaji Number:J1.636.337E
Wikidata:Q72486830
Mol file:136304-78-4.mol

Synonyms:136304-78-4;Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate;methyl 3-amino-2-[[4-(2-cyanophenyl)phenyl]methylamino]benzoate;methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate;Methyl 3-amino-2-{[(2'-cyanobiphenyl-4-yl)methyl]amino}benzoate;LERUETMARSWZRK-UHFFFAOYSA-N;Azilsartan pharMaceutical interMediate;SCHEMBL2927336;DTXSID60576392;BCP14163;AKOS016000560;AC-25905;AS-82418;A848324;methyl 3-amino-2-[(2'-cyanobiphenyl-4-yl)methylamino]benzoate;methyl 3-amino-2-[[(2'-cyanobiphenyi-4-yl)methyl]amino]benzoate;3-Amino-2-[(2'-cyano-biphenyl-4-ylmethyl)-amino]-benzoic acid methyl ester;Methyl 3-amino-2-{[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]amino}benzoate;Methyl3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate

Suppliers and Price of Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MethylEsterCandersartanReduzate
25mg
$ 815.00

TRC
MethylEsterCandersartanReduzate
50mg
$ 1540.00

Matrix Scientific
Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate 95+%
1g
$ 1647.00

Matrix Scientific
Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate 95+%
250mg
$ 742.00

American Custom Chemicals Corporation
METHYL-3-AMINO-2-(((2'-CYANO-[1,1'-BIPHENYL]-4-YL)METHYL)AMINO)BENZOATE 95.00%
5MG
$ 496.36

Alichem
Methyl3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate
1g
$ 448.80

Alichem
Methyl3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate
5g
$ 1383.70

AK Scientific
Methyl3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate
250mg
$ 1051.00

Total 22 raw suppliers

Chemical Property of Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate Edit

Chemical Property:

Melting Point:106-110℃
Boiling Point:584.3±50.0 °C(Predicted)
PKA:4.54±0.11(Predicted)
PSA：88.14000
Density:1.27
LogP:4.86038
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:357.147726857
Heavy Atom Count:27
Complexity:535

Purity/Quality:

98%min ^*data from raw suppliers

MethylEsterCandersartanReduzate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C(=CC=C1)N)NCC2=CC=C(C=C2)C3=CC=CC=C3C#N
Uses Methyl Ester Candersartan Reduzate is an impurity of the antihypertensive drug candesartan and azilsartan.

Technology Process of Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate

There total 13 articles about Methyl 3-amino-2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1228755-48-3
methyl 2-((2'-cyanobiphenyl-4-yl)methylamino)-5-iodo 3-nitrobenzoate

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

Guidance literature:: With ethanol; 5% Pd(II)/C(eggshell); at 20 - 40 ℃; Product distribution / selectivity;

Reference yield: 82.0%

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

Guidance literature:

Reference yield: 64.0%

: 139481-28-0
methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

Guidance literature:: methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate; With iron(III) chloride hexahydrate; pyrographite; In tetrahydrofuran; methanol; for 0.5h; Reflux;

With hydrazine hydrate; In tetrahydrofuran; methanol; for 14h; Reflux;