6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

Base Information

• Chemical Name: 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one
• CAS No.: 1286739-19-2
• Molecular Formula: C29H28ClN7OS
• Molecular Weight: 558.107
• Mol file: 1286739-19-2.mol

Synonyms:FRAX597

Chemical Property of 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

Chemical Property:

• PSA: 110.65000
• LogP: 5.97750
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

FRAX 597 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p21-activated kinases (Paks) are serine/threonine protein kinases involved in cellular signaling pathways. PAK1 is an effector of Rho GTPase. PAKs are oncogenic kinases, which have been implicated as potential therapeutic targets. FRAX 597 is a PAK1 inhibitor that can reduce pancreatic cancer growth when used with Gemcitabine (G305000), an antineoplastic agent.

Technology Process of 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one

There total 1 articles about 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-l-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one (1286739-19-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 140 ℃; for 1.5h; Microwave irradiation; Inert atmosphere;

Refernces