3-Pyridinecarboxamide,5-hydroxy-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxamide,5-hydroxy-(9CI)
• CAS No.: 101512-21-4
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933399090
• Mol file: 101512-21-4.mol

Synonyms:5-Hydroxynicotinamide;NSC 605536;SR 4364;

Chemical Property of 3-Pyridinecarboxamide,5-hydroxy-(9CI)

Chemical Property:

• Vapor Pressure: 8.24E-10mmHg at 25°C
• Melting Point: 222-224 °C
• Refractive Index: 1.622
• Boiling Point: 479.3 °C at 760 mmHg
• PKA: 8.54±0.10(Predicted)
• Flash Point: 243.7 °C
• PSA: 76.21000
• Density: 1.384 g/cm³
• LogP: 0.58640

Purity/Quality:

99.00% ^*data from raw suppliers

5-Hydroxypyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 3-Pyridinecarboxamide, 5-hydroxy-(9CI), also known as nicotinamide or niacinamide, has diverse applications in various fields. In the realm of skincare and cosmetics, it is a key ingredient known for its role in promoting skin health. Nicotinamide is used in skincare products for its ability to improve skin barrier function, reduce inflammation, and address issues such as acne, hyperpigmentation, and fine lines. In the field of nutrition and pharmaceuticals, nicotinamide is a form of vitamin B3 and is essential for overall health. It plays a critical role in the synthesis of coenzymes involved in various metabolic processes. In addition, nicotinamide is used in the pharmaceutical industry for the treatment of certain medical conditions, including pellagra and skin disorders. Its multifaceted utility underscores its significance in advancing skincare, nutrition, and healthcare, where it plays a pivotal role in promoting skin wellness, metabolic functions, and therapeutic treatments.

Technology Process of 3-Pyridinecarboxamide,5-hydroxy-(9CI)

There total 2 articles about 3-Pyridinecarboxamide,5-hydroxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 5-hydroxy-3-pyridinecarboxylate (59288-38-9) → 5-hydroxypyridine-3-carboxamide (101512-21-4)

Guidance literature:

With ammonium hydroxide; for 24h; Ambient temperature;

DOI:10.1007/BF00766873

Reference yield:

→ 5-hydroxypyridine-3-carboxamide (101512-21-4)

Guidance literature:

Reference yield: 96.0%

1-(3-nitrophenyl)ethanol (5400-78-2) + 5-hydroxypyridine-3-carboxamide (101512-21-4) → methyl 5-(1-(3-nitrophenyl)ethoxy)nicotinate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

upstream raw materials:

ethyl 5-hydroxy-3-pyridinecarboxylate

Refernces

• 1、 Stolyarova, L. G.,Akhundov, R. A.,Rakhmankulova, I. Kh.,Voronina, T. A.,Smirnov, L. D.,Dyumaev, K. M.. "SYNTHESIS AND PSYCHOPHARMACOLOGICAL AND ANTIHYPOXIC ACTIVITY OF SOME &β-SUBSTITUTED PYRIDINECARBOXYLIC ACIDS". . p. 29 - 31. Retrieved 2007/10/02.