5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole

Base Information Edit

Chemical Name:5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole
CAS No.:154709-18-9
Molecular Formula:C33H26N4O
Molecular Weight:494.596
Hs Code.:
DSSTox Substance ID:DTXSID20568450
Wikidata:Q82454705
Mol file:154709-18-9.mol

Synonyms:154709-18-9;5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole;Olmesartan Impurity;[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methanol;2'-[1-(Triphenylmethyl)-1H-tetrazol-5-yl]-[1,1'-biphenyl]-4-methanol;5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-2-triphenylmethyltetrazole;QTMWXNFBOZZDCQ-UHFFFAOYSA-N;SCHEMBL9024777;DTXSID20568450;AKOS040756892;HY-133775;CS-0131912;F19410;4-(Hydroxymethyl)-2'-(1-triphenylmethyltetrazol-5-yl)biphenyl;{2'-[1-(Triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl}methanol;5-[4 inverted exclamation mark -Hydroxymethyl-(1,1 inverted exclamation mark -biphenyl)-2-yl]-2-triphenylmethyltetrazole

Suppliers and Price of 5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-2-triphenylmethyltetrazole
100 mg
$ 500.00

Total 9 raw suppliers

Chemical Property of 5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole Edit

Chemical Property:

Boiling Point:724.8±70.0 °C(Predicted)
PKA:14.25±0.10(Predicted)
Flash Point:392.1oC
PSA：63.83000
Density:1.17±0.1 g/cm3(Predicted)
LogP:6.33960
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly, Heated)
XLogP3:6.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:494.21066147
Heavy Atom Count:38
Complexity:660

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-2-triphenylmethyltetrazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C(=NN=N4)C5=CC=CC=C5C6=CC=C(C=C6)CO
Uses Intermediate in the preparation of Losartan impurity J.

Technology Process of 5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole

There total 10 articles about 5-[4'-Hydroxymethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.93%

: 155983-56-5
5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole

: 154709-18-9
4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl

Guidance literature:: 5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole; With sodium tetrahydroborate; In methanol; at 5 - 20 ℃; for 1h;

With water; In methanol; at 0 ℃; for 0.25h;

Reference yield: 89.1%

: 160514-13-6
5-(4'-hydroxymethyl-biphenyl-2-yl)-1H-tetrazole

: 76-83-5
trityl chloride

: 154709-18-9
4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl

Guidance literature:: 5-(4'-hydroxymethyl-biphenyl-2-yl)-1H-tetrazole; With triethylamine; In dichloromethane; at 10 - 15 ℃;

trityl chloride; In dichloromethane; at 10 ℃; Reflux;