5-(3-Chlorophenyl)-3-Methoxypicolinonitrile

Base Information

• Chemical Name: 5-(3-Chlorophenyl)-3-Methoxypicolinonitrile
• CAS No.: 1415226-39-9
• Molecular Formula: C13H9ClN2O
• Molecular Weight: 244.68
• Hs Code.: 2933399090
• Mol file: 1415226-39-9.mol

Synonyms:5-(3-Chlorophenyl)-3-Methoxypicolinonitrile

Chemical Property of 5-(3-Chlorophenyl)-3-Methoxypicolinonitrile

Chemical Property:

• PSA: 45.91000
• LogP: 3.28228

Purity/Quality:

99.9% ^*data from raw suppliers

5-(3-Chlorophenyl)-3-methoxypicolinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-Chlorophenyl)-3-Methoxypicolinonitrile

There total 7 articles about 5-(3-Chlorophenyl)-3-Methoxypicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 5-(3-chlorophenyl)-3-chloro-2-cyanopyridine (1415226-38-8) → 5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine (1415226-39-9)

Guidance literature:

With sodium methylate; for 24h; Inert atmosphere; Reflux;

Reference yield: 82.0%

5-(3-chlorophenyl)-3-chloro-2-cyanopyridine (1415226-38-8) + sodium methylate (124-41-4) → 5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine (1415226-39-9)

Guidance literature:

With methanol; for 24h; Product distribution / selectivity; Reflux; Inert atmosphere;

Reference yield:

2-Cyano-3,5-dichloropyridine (85331-33-5) → 5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine (1415226-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 25.5 h / 50 °C / Inert atmosphere

2: methanol / 24 h / Reflux; Inert atmosphere

With methanol; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide;

upstream raw materials:

5-(3-chlorophenyl)-3-chloro-2-cyanopyridine

sodium methylate

3-chlorophenylboronic acid

2-Cyano-3,5-dichloropyridine

Downstream raw materials:

5-(3-chlorophenyl)-3-hydroxy-pyridine-2-carboxylic acid carbamoylmethyl-amide

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxylic acid

Refernces

• 1、 Lin, Biyue,Kou, Jingping,Wu, Shuming,Cai, Xuerong,Xiao, Qingbo,Li, Yinglong,Hu, Jian,Li, Jianbing,Wang, Zhongqing. "Development of a Robust and Scalable Process for the Large-Scale Preparation of Vadadustat". supporting information. p. 960 - 968. Retrieved 2021/04/05.
• 2、 -. "DEUTERIUM-ENRICHED HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE ENZYME INHIBITORS". Paragraph 00129. . Retrieved 2016/10/11.