N-Ethyl-3-fluoro-benzenaMine

Base Information

• Chemical Name: N-Ethyl-3-fluoro-benzenaMine
• CAS No.: 2707-62-2
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 2921420090
• Mol file: 2707-62-2.mol

Synonyms:N-Ethyl-3-fluoro-benzenaMine;Benzenamine, N-ethyl-3-fluoro-

Chemical Property of N-Ethyl-3-fluoro-benzenaMine

Chemical Property:

• PSA: 12.03000
• LogP: 2.33050

Purity/Quality:

99.90% ^*data from raw suppliers

Benzenamine,N-ethyl-3-fluoro- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Ethyl-3-fluoro-benzenaMine

There total 7 articles about N-Ethyl-3-fluoro-benzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(3-fluorophenyl)acetamide (351-28-0) → meta-fluoroaniline (372-19-0) + N-ethyl-3-fluoroaniline (2707-62-2)

Guidance literature:

With dihydridocarbonyl(1,1,1-tris(diphenylphosphinomethyl)ethane)ruthenium(II) complex; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; at 120 ℃; for 16h; under 38002.6 Torr; Glovebox; Autoclave; Inert atmosphere;

DOI:10.1002/cctc.201600635

Reference yield: 80.0%

meta-fluoroaniline (372-19-0) + acetaldehyde (75-07-0,9002-91-9) → N-ethyl-3-fluoroaniline (2707-62-2)

Guidance literature:

With 4 A molecular sieve; borane pyridine complex; In methanol; for 14h;

DOI:10.1021/jm021065a

Reference yield: 43.0%

meta-fluoroaniline (372-19-0) + orthoformic acid triethyl ester (122-51-0) → N-ethyl-3-fluoroaniline (2707-62-2)

Guidance literature:

meta-fluoroaniline; orthoformic acid triethyl ester;

In water; Acidic conditions;

DOI:10.1007/s11172-012-0124-4

upstream raw materials:

meta-fluoroaniline

acetaldehyde

ethyl vinyl ether

orthoformic acid triethyl ester

Downstream raw materials:

N₆,N₆'-diethyl-N₆,N₆'-di(3-fluorophenyl)-[2,2'-bipyridine]-6,6'-dicarboxamide

2-[ethyl(3-fluorophenyl)carbamoyl]cyclopent-2-enecarboxylic acid methyl ester

C₉H₉ClFNO

Refernces

• 1、 Eisen, Moris S.,Saha, Sayantani. "Mild catalytic deoxygenation of amides promoted by thorium metallocene". . p. 12835 - 12841. Retrieved 2020/10/05.
• 2、 Yuan, Ming-Lei,Xie, Jian-Hua,Zhou, Qi-Lin. "Boron Lewis Acid Promoted Ruthenium-Catalyzed Hydrogenation of Amides: An Efficient Approach to Secondary Amines". . p. 3036 - 3040. Retrieved 2016/10/11.