5-bromo-4-methyl-2-phenylPyridine

Base Information

• Chemical Name: 5-bromo-4-methyl-2-phenylPyridine
• CAS No.: 31686-64-3
• Molecular Formula: C12H10BrN
• Molecular Weight: 248.122
• Mol file: 31686-64-3.mol

Synonyms:5-bromo-4-methyl-2-phenylPyridine

Chemical Property of 5-bromo-4-methyl-2-phenylPyridine

Chemical Property:

• Boiling Point: 321.5±37.0 °C(Predicted)
• PKA: 2.71±0.18(Predicted)
• PSA: 12.89000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 3.81950

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-methyl-2-phenyl-pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-4-methyl-2-phenylPyridine

There total 2 articles about 5-bromo-4-methyl-2-phenylPyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,5-Dibromo-4-methylpyridine (3430-26-0) + phenylboronic acid (98-80-6) → 5-bromo-4-methyl-2-phenylpyridine (31686-64-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

→ 5-bromo-4-methyl-2-phenylpyridine (31686-64-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 120 ℃; for 2h; Inert atmosphere;

Reference yield: 98.0%

Trimethylboroxine (823-96-1) + 5-bromo-4-methyl-2-phenylpyridine (31686-64-3) → 4,5-dimethyl-2-phenylpyridine (27063-84-9)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; toluene; at 110 ℃; for 23h; Inert atmosphere;

upstream raw materials:

2,5-Dibromo-4-methylpyridine

phenylboronic acid

Downstream raw materials:

C₄₆H₃₅IrN₄

4,5-dimethyl-2-phenylpyridine

Refernces

• 1、 -. "N - aryl - hydrogel arc [tin [tin] light-emitting electroluminescent device as a component of". Paragraph 0131-0132. . Retrieved 2018/05/15.
• 2、 -. "ORGANOMETALLIC COMPLEX, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE". Paragraph 0330; 0331; 0332. . Retrieved 2017/10/31.