4-Acetoxy-3-methoxybenzoic acid methyl ester

Base Information

• Chemical Name: 4-Acetoxy-3-methoxybenzoic acid methyl ester
• CAS No.: 35400-19-2
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Mol file: 35400-19-2.mol

Synonyms:4-Acetoxy-3-methoxybenzoic acid methyl ester

Chemical Property of 4-Acetoxy-3-methoxybenzoic acid methyl ester

Chemical Property:

• PSA: 61.83000
• LogP: 1.40710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Acetoxy-3-methoxybenzoic acid methyl ester

There total 2 articles about 4-Acetoxy-3-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) + acetyl chloride (75-36-5) → 4-(acetyloxy)-3-methoxybenzoic acid methyl ester (35400-19-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/cb200332k

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) + acetic anhydride (108-24-7) → 4-(acetyloxy)-3-methoxybenzoic acid methyl ester (35400-19-2)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jo01208a017

Reference yield:

4-(acetyloxy)-3-methoxybenzoic acid methyl ester (35400-19-2) → 4-acetoxy-2-bromo-5-methoxy-benzoic acid methyl ester

Guidance literature:

With bromine; iodine; sodium acetate; acetic acid;

DOI:10.1021/jo01208a017

upstream raw materials:

4-hydroxy-3-methoxybenzoic acid methyl ester

acetic anhydride

acetyl chloride

Refernces