Quazepam

Base Information

• Chemical Name: Quazepam
• CAS No.: 36735-22-5
• Molecular Formula: C17H11 Cl F4 N2 S
• Molecular Weight: 386.8
• Hs Code.: 2933996500
• European Community (EC) Number: 253-179-4
• NSC Number: 309702
• UNII: JF8V0828ZI
• DSSTox Substance ID: DTXSID60190193
• Nikkaji Number: J17.787C
• Wikipedia: Quazepam
• Wikidata: Q3927403
• NCI Thesaurus Code: C47699
• RXCUI: 35185
• Pharos Ligand ID: HFP2XRFAYA6S
• Metabolomics Workbench ID: 43580
• ChEMBL ID: CHEMBL1200472
• Mol file: 36735-22-5.mol

Synonyms:Doral;quazepam;Quiedorm;Sch 16134;Sch-16134

Chemical Property of Quazepam

Chemical Property:

• Vapor Pressure: 1.35E-07mmHg at 25°C
• Melting Point: 22°C
• Boiling Point: 429.9 °C at 760 mmHg
• PKA: 0.49±0.20(Predicted)
• Flash Point: 213.8 °C
• PSA: 47.69000
• Density: 1.42 g/cm³
• LogP: 4.52680
• Storage Temp.: -20°C
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 386.0267599
• Heavy Atom Count: 25
• Complexity: 539

Purity/Quality:

98%,99%, ^*data from raw suppliers

Quazepam United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Sedatives and Hypnotics
• Canonical SMILES: C1C(=S)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CC(F)(F)F
• Description: Quazepam is a rapidly acting, short term hypnotic reported to exhibit a low incidence of side effects.
• Uses: Quazepam is a benzodiazepine derivative drug and is known to bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activty, motor coordination and memory. Quazepam is known to induce motor impairment and exerts hypnotic properties. Quazepam is often used for the treatment of insomina.

Technology Process of Quazepam

There total 1 articles about Quazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ quazepam (36735-22-5)

Guidance literature:

Verb.42, P2S5;

DOI:10.1021/jm00270a008

Reference yield: 100.0%

quazepam (36735-22-5) → [3H]-2-Oxoquazepam (49606-44-2)

Guidance literature:

With Hg(CH₃COO)2; at 20 ℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator;

DOI:10.1002/ardp.19883210806

Reference yield: 42.0%

mercaptoacetic acid (68-11-1) + quazepam (36735-22-5) → 10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

Guidance literature:

In benzene; for 45h; Heating;

Downstream raw materials:

[3H]-2-Oxoquazepam