O-Desethyl Candesartan Cilexetil

Base Information

• Chemical Name: O-Desethyl Candesartan Cilexetil
• CAS No.: 869631-11-8
• Molecular Formula: C31H29N6O6
• Molecular Weight: 582.616
• Hs Code.: 29339900
• Mol file: 869631-11-8.mol

Synonyms:O-Desethyl Candesartan Cilexetil ;2,3-Dihydro-2-oxo-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-benziMidazole-4-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester;Candesartan Cilexetil EP IMpurity B

Chemical Property of O-Desethyl Candesartan Cilexetil

Chemical Property:

• Melting Point: 237-239?C (dec.)
• PKA: 4.16±0.10(Predicted)
• PSA: 154.34000
• Density: 1.437g/cm³
• LogP: 5.62600
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

O-DesethylCandesartanCilexetil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: O-Desethyl Candesartan Cilexetil (Candesartan Cilexetil EP Impurity B) is used for the preparation of Candesartan Cilexetil (CAT# C175580), which is an antihypertensive. It may be obtained as a degradation product of Candesartan Cilexetil in liquid chromatography studies. O-Desethyl Candesartan Cilexetil can be used for the preparation of Candesartan cilexetil.

Technology Process of O-Desethyl Candesartan Cilexetil

There total 5 articles about O-Desethyl Candesartan Cilexetil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

candesartan cilexetil (145040-37-5) → (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate (869631-11-8)

Guidance literature:

With hydrogenchloride; water; In acetone; for 6h; Reflux;

DOI:10.1135/cccc2008072

Reference yield: 69.7%

cilexetil trityl candesartan (170791-09-0) → (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate (869631-11-8)

Guidance literature:

With hydrogenchloride; water; In acetone; for 6h; Reflux;

DOI:10.1135/cccc2008072

Reference yield:

cilexetil trityl candesartan (170791-09-0) → (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-oxo-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-2,3-dihydro-1H-benzimidazole-4-carboxylate (869631-11-8) + candesartan cilexetil (145040-37-5)

Guidance literature:

With methanol; for 24h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

candesartan cilexetil

cilexetil trityl candesartan

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL". Page/Page column 16-17. . Retrieved 2008/06/13.