3,4-DIFLUOROBENZYLSULFONYL CHLORIDE

Base Information

• Chemical Name: 3,4-DIFLUOROBENZYLSULFONYL CHLORIDE
• CAS No.: 163295-73-6
• Molecular Formula: C₇H₅ClF₂O₂S
• Molecular Weight: 226.631
• Hs Code.: 2904909090
• Mol file: 163295-73-6.mol

Synonyms:3,4-DIFLUOROBENZYLSULFONYL CHLORIDE;(3,4-Difluorophenyl)methylsulphonyl chloride;3,4-Difluorobenzylsulphonyl chloride;(3,4-Difluorophenyl)methanesulphonyl chloride;alpha-(Chlorosulphonyl)-3,4-difluorotoluene

Chemical Property of 3,4-DIFLUOROBENZYLSULFONYL CHLORIDE

Chemical Property:

• PSA: 42.52000
• LogP: 3.11420

Purity/Quality:

98%Min ^*data from raw suppliers

3,4-Difluorobenzylsulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DIFLUOROBENZYLSULFONYL CHLORIDE

There total 3 articles about 3,4-DIFLUOROBENZYLSULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium sulfite (7757-83-7) → (3,4-difluorophenyl)methanesulfonyl chloride (163295-73-6)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 1h;

Reference yield:

thionyl chloride (7719-09-7) + 3,4-difluorobenzyl sodium sulfonate (540523-03-3) → (3,4-difluorophenyl)methanesulfonyl chloride (163295-73-6)

Guidance literature:

With N,N-dimethyl-formamide; In dichloromethane; for 1h;

Reference yield:

4-(chloromethyl)-1,2-difluorobenzene (698-80-6) → (3,4-difluorophenyl)methanesulfonyl chloride (163295-73-6)

Guidance literature:

4-(chloromethyl)-1,2-difluorobenzene; With thiourea; In ethanol; at 96 ℃;

With hydrogenchloride; In water; acetonitrile; at 0 ℃; for 0.25h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃;

DOI:10.1002/anie.201701579

upstream raw materials:

sodium sulfite

thionyl chloride

3,4-difluorobenzyl sodium sulfonate

4-(chloromethyl)-1,2-difluorobenzene

Refernces

• 1、 Modak, Atanu,Patra, Tuhin,Chowdhury, Rajdip,Raul, Suman,Maiti, Debabrata. "Palladium-Catalyzed Remote meta-Selective C-H Bond Silylation and Germanylation". supporting information. p. 2418 - 2423. Retrieved 2017/07/17.
• 2、 -. "Process for making an aldehyde". Page 13. . Retrieved 2008/06/13.