Technology Process of ethyl 5-benzyl-4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazine-2-carboxylate
There total 3 articles about ethyl 5-benzyl-4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazine-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 1h;
benzyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
3.2: 16 h / 20 °C
With
hydrogenchloride; sodium hydride; caesium carbonate;
In
1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C
2.2: 16 h / 20 °C
With
hydrogenchloride; sodium hydride;
In
1,4-dioxane; N,N-dimethyl-formamide; mineral oil;