S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate

Base Information

• Chemical Name: S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate
• CAS No.: 68935-26-2
• Molecular Formula: C40H46N4O8
• Molecular Weight: 548.593
• Mol file: 68935-26-2.mol

Synonyms:S-(-)-Nicotine Di-p-Toluoyl-D-Tartrate Salt

Chemical Property of S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate

Chemical Property:

• PSA: 143.33000
• LogP: 4.00980

Purity/Quality:

98% ^*data from raw suppliers

S-(-)-NicotineDi-p-Toluoyl-D-TartrateSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate is used in the synthesis of optically pure Nicotine.

Technology Process of S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate

There total 5 articles about S-(-)-3-(1-Methyl-2-pyrrolidinyl)pyridiniuM (+)-Di-p-toluoyl Tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Di-p-toluoyl-L-tartaric acid (32634-66-5) + 3-(1-methyl-pyrrolidin-2-yl)-pyridine (22083-74-5) → l-nicotine di-(p-toluoyl)-l-tartrate (68935-26-2)

Guidance literature:

In methanol; isopropyl alcohol; at 25 ℃; for 2.25h; Solvent; Temperature; Concentration; Reflux;

Reference yield:

C10H14N2*C20H18O8 → l-nicotine di-(p-toluoyl)-l-tartrate (68935-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water

1.2: 0.17 h / 240 °C / Inert atmosphere

2.1: isopropyl alcohol; methanol / 2.25 h / 25 °C / Reflux

With hydrogenchloride; In methanol; water; isopropyl alcohol;

Reference yield:

C11H11N2O2(1-)*K(1+) → l-nicotine di-(p-toluoyl)-l-tartrate (68935-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 68 h / 20 °C / Reflux; Large scale

1.2: 4 h / 5 - 60 °C / pH Ca_. 8 - Ca_. 11 / Large scale

2.1: isopropyl alcohol; methanol / 2.25 h / 25 °C / Reflux

With hydrogenchloride; In methanol; water; isopropyl alcohol;

upstream raw materials:

Di-p-toluoyl-L-tartaric acid

3-(1-methyl-pyrrolidin-2-yl)-pyridine

methyl 3-pyridinecarboxylate

Downstream raw materials:

nicotin

Refernces

• 1、 Bowman, Edward R.,McKennis, Herbert,Martin, Billy R.. "A CONVENIENT METHOD FOR THE PREPARATION OF RACEMIC NICOTINE". . p. 871 - 880. Retrieved 2007/10/02.