AGI6780

Base Information

• Chemical Name: AGI6780
• CAS No.: 1432660-47-3
• Molecular Formula: C21H18F3N3O3S2
• Molecular Weight: 481.5111296
• Hs Code.: 2935909099
• Mol file: 1432660-47-3.mol

Synonyms:AGI6780;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780;AGI-6780, >=98%

Chemical Property of AGI6780

Chemical Property:

• PKA: 11.78±0.20(Predicted)
• PSA: 127.41000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 7.07690
• Solubility.: ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

AGI-6780 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
• Uses: AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.

Technology Process of AGI6780

There total 1 articles about AGI6780 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ AGI-6780 (1432660-47-3)

Guidance literature:

With trichloroacetonitrile; triphenylphosphine; In dichloromethane; for 1h; Reflux;

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;

Refernces