4-Methoxybenzylhydrazine dihydrochloride

Base Information

• Chemical Name: 4-Methoxybenzylhydrazine dihydrochloride
• CAS No.: 412327-07-2
• Molecular Formula: C8H14Cl2N2O
• Molecular Weight: 225.11556
• Hs Code.: 2928009090
• Mol file: 412327-07-2.mol

Synonyms:(4-Methoxyphenyl)Methyl]-hydrazine dichlorhydrate;[(4-methoxyphenyl)methyl]hydrazine dihydrochloride

Chemical Property of 4-Methoxybenzylhydrazine dihydrochloride

Chemical Property:

• PSA: 47.28000
• LogP: 3.35370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Methoxybenzyl)hydrazineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (4-Methoxybenzyl)hydrazine Dihydrochloride is used in preparation of Heterocyclic derivatives useful as SHP2 inhibitors.

Technology Process of 4-Methoxybenzylhydrazine dihydrochloride

There total 6 articles about 4-Methoxybenzylhydrazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-1-(tert-butoxycarbonyl)-N-2-<(4-methoxyphenyl)methyl>hydrazine (150767-02-5) → [(4-methoxyphenyl)methyl] hydrazine dihydrochloride (412327-07-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 17h;

Reference yield: 80.0%

p-methoxybenzyl chloride (824-94-2) → 1-(4-methoxybenzyl)hydrazine hydrochloride (2011-48-5,412327-07-2)

Guidance literature:

p-methoxybenzyl chloride; With hydrazine hydrate; In methanol; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; for 3h;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → [(4-methoxyphenyl)methyl] hydrazine dihydrochloride (412327-07-2)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethanol;

upstream raw materials:

p-methoxybenzyl chloride

N-1-(tert-butoxycarbonyl)-N-2-<(4-methoxyphenyl)methyl>hydrazine

4-methoxy-benzaldehyde

Downstream raw materials:

1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-5-amine

1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-amine

Refernces

• 1、 -. "EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO". Paragraph 1027; 1028. . Retrieved 2017/08/01.
• 2、 -. "SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS". Page/Page column 84; 85. . Retrieved 2014/10/04.