3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt

Base Information

• Chemical Name: 3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt
• CAS No.: 1294517-15-9
• Molecular Formula: C41H45NO11
• Molecular Weight: 727.808
• Mol file: 1294517-15-9.mol

Synonyms:3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt;Methyl 3-[(1R)-3-[Bis(;Methyl 3-[(1R)-3-[Bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-hydroxybenzoate (2S,3S)-2,3-Bis(benzoyloxy)-butanedioic Acid

Chemical Property of 3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt

Chemical Property:

• PSA: 176.97000
• LogP: 6.42640
• Solubility.: Dimethylfomamide, Dimethyl Sulfoxide

Purity/Quality:

98%min ^*data from raw suppliers

3-[(1R)-3-Bisisopropylamino-1-phenylpropyl-4-hydroxyBenzoicAcidMethylEsterDibenzoyl-D-tartaricAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Carboxy Tolterodine (C183210) derivative, a metabolite of Tolterodine (T535800).

Technology Process of 3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt

There total 3 articles about 3-[(1R)-3-BisisopropylaMino-1-phenylpropyl-4-hydroxy Benzoic Acid Methyl Ester Dibenzoyl-D-tartaric Acid Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diisopropyl-3-(2-hydroxy-5-methyloxycarbonylphenyl)-3-phenylpropanamine (214601-16-8) + O,O'-dibenzoyl-D-tartaric acid (17026-42-5) → methyl (R)-(-)-3-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoate 2,3-dibenzoyl-D-tartaric acid salt (1294517-15-9)

Guidance literature:

In ethanol; at 20 - 60 ℃; Inert atmosphere;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → methyl (R)-(-)-3-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoate 2,3-dibenzoyl-D-tartaric acid salt (1294517-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonic acid / water / 50 - 55 °C / Inert atmosphere

2: ethanol / 60 °C / Inert atmosphere

With methanesulfonic acid; In ethanol; water;

Reference yield:

3-(N,N-diisopropylamino)-1-phenylpropan-1-ol (906532-26-1) → methyl (R)-(-)-3-(3-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoate 2,3-dibenzoyl-D-tartaric acid salt (1294517-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonic acid / water / 50 - 55 °C / Inert atmosphere

2: ethanol / 60 °C / Inert atmosphere

With methanesulfonic acid; In ethanol; water;

upstream raw materials:

N,N-diisopropyl-3-(2-hydroxy-5-methyloxycarbonylphenyl)-3-phenylpropanamine

O,O'-dibenzoyl-D-tartaric acid

methyl 4-hydroxylbenzoate

3-(N,N-diisopropylamino)-1-phenylpropan-1-ol

Downstream raw materials:

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

fesoterodine

(R)-(-)-3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzoic acid methyl ester

Refernces

• 1、 -. "Process for the preparation of fesoterodine". Page/Page column 9. . Retrieved 2011/05/08.
• 2、 -. "A process for the preparation of fesoterodine with low impurities content". Page/Page column 9. . Retrieved 2011/07/09.