2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate

Base Information

• Chemical Name: 2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate
• CAS No.: 1245157-85-0
• Molecular Formula: C24H28ClN7O3S
• Molecular Weight: 530.05
• Hs Code.: 2933399990
• Mol file: 1245157-85-0.mol

Synonyms:2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate

Chemical Property of 2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate

Chemical Property:

• PKA: 10.94±0.70(Predicted)
• PSA: 140.82000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 4.03320

Purity/Quality:

95+% ^*data from raw suppliers

2-(4-(6-((5-((2-Chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)-amino)-2-methylpyrimidin-4-yl)piperazin-1-yl)ethyl acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate

There total 17 articles about 2-(4-(6-((5-((2-chloro-6-Methylphenyl)carbaMoyl)thiazol-2-yl)aMino)-2-MethylpyriMidin-4-yl)piperazin-1-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid (1245157-80-5) + 2-chloro-6-methylaniline (87-63-8) → N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide (1245157-85-0)

Guidance literature:

2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid; With thionyl chloride; sodium hydroxide; In water; 1,2-dichloro-ethane; at 55 - 60 ℃; for 4h;

2-chloro-6-methylaniline; With triethylamine; In 1,2-dichloro-ethane; at 40 - 45 ℃; for 1h; Solvent; Reagent/catalyst; Temperature;

Reference yield: 86.0%

acetic acid (64-19-7,77671-22-8) + dasatanib (302962-49-8) → N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide (1245157-85-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 25h; Inert atmosphere; Cooling with ice;

DOI:10.1002/cmdc.201600387

Reference yield:

2-(6-(4-(2-acetoxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formyl chloride (1245158-44-4) + 2-chloro-6-methylaniline (87-63-8) → N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl- 4-pyrimidinyl]amino]-5-thiazolecarboxamide (1245157-85-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

upstream raw materials:

1-(2-hydroxyethyl)piperazine

2,4-dichloro-2-methylpyrimidine

2-[[6-[4-(2-acetoxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

2-chloro-6-methylaniline

Downstream raw materials:

dasatanib

Refernces

• 1、 -. "Preparation method of Dasatinib". Paragraph 0066; 0078-0081. . Retrieved 2019/02/10.
• 2、 -. "SYNTHESIS PROCESS OF DASATINIB AND INTERMEDIATE THEREOF". . . Retrieved 2013/02/27.