Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid

Base Information

• Chemical Name: Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid
• CAS No.: 95022-60-9
• Molecular Formula: C₁₇H₂₅N₃O₅
• Molecular Weight: 351.403
• Mol file: 95022-60-9.mol

Synonyms:Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid;CBZ-Glu(NHNH2)-OtBu

Chemical Property of Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid

Chemical Property:

• Melting Point: 110 °C
• Boiling Point: 570.2±50.0 °C(Predicted)
• PKA: 10.80±0.46(Predicted)
• PSA: 119.75000
• Density: 1.184±0.06 g/cm3(Predicted)
• LogP: 2.87530

Purity/Quality:

98.5% ^*data from raw suppliers

Z-GLU(NHNH2)-OTBU 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid

There total 3 articles about Z-L-Glutamic acid γ-tert·butyl ester γ-hydrazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate (81470-51-1) → benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide (95022-60-9)

Guidance literature:

With hydrazine hydrate;

Reference yield:

acetic acid tert-butyl ester (540-88-5) + N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide (4510-09-2) → benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide (95022-60-9)

Guidance literature:

With perchloric acid;

Reference yield:

acetic acid tert-butyl ester (540-88-5) + (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester (4652-65-7) → benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide (95022-60-9)

Guidance literature:

Multistep reaction; (i) HClO₄, (ii) N₂H₄*H₂O, MeOH;

upstream raw materials:

acetic acid tert-butyl ester

N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester

tert-butyl N-benzyloxycarbonyl-L-pyroglutamate

Downstream raw materials:

N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert-butylester)-S-benzyl-cystein-methylester

tert-butyl 2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyrate

2-(benzyloxycarbonyl)amino-4-(4,6-dimethyl-2-oxo-1,2-dihydropyrimidin-1-yl)butyric acid

N-<3-(benzyloxycarbonyl)amino-3-tert-butoxycarbonylpropyl>urea