BOC-DL-O-TYROSINE

Base Information

• Chemical Name: BOC-DL-O-TYROSINE
• CAS No.: 203569-04-4
• Molecular Formula: C14H19NO5
• Molecular Weight: 281.3
• Mol file: 203569-04-4.mol

Synonyms:BOC-DL-O-TYROSINE;(R,S)-N-(tert-butoxycarbonyl)-o-tyrosine;Boc-2-hydroxy-DL-phenylalanine

Chemical Property of BOC-DL-O-TYROSINE

Chemical Property:

• PSA: 95.86000
• LogP: 2.30350

Purity/Quality:

98%Min ^*data from raw suppliers

Boc-DL-o-tyrosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-DL-O-TYROSINE

There total 1 articles about BOC-DL-O-TYROSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-hydroxy-phenylalanine (709-16-0,2370-61-8,7423-92-9,24008-77-3) → (R,S)-N-(tert-butoxycarbonyl)-o-tyrosine (203569-04-4,119660-45-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jm970276q

Reference yield:

(R,S)-N-(tert-butoxycarbonyl)-o-tyrosine (203569-04-4,119660-45-6) → β-[2-(carboxymethoxy)phenyl]-α-alanine hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) acetone, 50 deg C, 1.5 h, 2.) acetone, 50 deg C, 7 h

2: 2N HCl / 24 h / Heating

With hydrogenchloride; potassium carbonate;

DOI:10.1021/jm970276q

Reference yield:

ethyl bromoacetate (105-36-2) + (R,S)-N-(tert-butoxycarbonyl)-o-tyrosine (203569-04-4,119660-45-6) → 2-tert-Butoxycarbonylamino-3-(2-ethoxycarbonylmethoxy-phenyl)-propionic acid

Guidance literature:

With potassium carbonate; Multistep reaction; 1.) acetone, 50 deg C, 1.5 h, 2.) acetone, 50 deg C, 7 h;

DOI:10.1021/jm970276q

upstream raw materials:

di-tert-butyl dicarbonate

2-hydroxy-phenylalanine

Refernces