N,N'-Dibenzyl-1,3-propanediamine

Base Information

• Chemical Name: N,N'-Dibenzyl-1,3-propanediamine
• CAS No.: 10239-34-6
• Molecular Formula: C17H22N2
• Molecular Weight: 254.375
• Hs Code.: 2921590090
• Mol file: 10239-34-6.mol

Synonyms:1,3-Propanediamine,N,N'-bis(phenylmethyl)- (9CI);1,3-Propanediamine, N,N'-dibenzyl- (6CI,8CI);N,N'-Dibenzyl-1,3-diaminopropane;N,N'-Dibenzyl-1,3-propanediamine;N,N'-Dibenzyl-1,3-propylenediamine;N,N'-Dibenzyltrimethylenediamine;

Chemical Property of N,N'-Dibenzyl-1,3-propanediamine

Chemical Property:

• Boiling Point: 389.8 °C at 760 mmHg
• PKA: 9.73±0.19(Predicted)
• Flash Point: 230.2 °C
• PSA: 24.06000
• Density: 1.017 g/cm³
• LogP: 3.73790
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N''-Dibenzyl-1,3-diaminopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,N''-Dibenzyl-1,3-diaminopropane is a hepatitis C virus inhibitor.

Technology Process of N,N'-Dibenzyl-1,3-propanediamine

There total 21 articles about N,N'-Dibenzyl-1,3-propanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzaldehyde (100-52-7) + Trimethylenediamine (109-76-2,54018-94-9) → N,N'-dibenzyl-1,3-diaminopropane (10239-34-6)

Guidance literature:

benzaldehyde; Trimethylenediamine; With sodium sulfate; In dichloromethane; at 20 ℃; for 18h;

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;

Reference yield: 96.0%

N,N'-bisbenzylidene-1,3-diaminopropane (63674-16-8) → N,N'-dibenzyl-1,3-diaminopropane (10239-34-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.25h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1515/znb-2016-0011

Reference yield: 81.0%

benzyl chloride (100-44-7) + Trimethylenediamine (109-76-2,54018-94-9) → N,N'-dibenzyl-1,3-diaminopropane (10239-34-6) + N-benzyl-1,3-diaminopropane (13910-48-0)

Guidance literature:

In ethanol; at 20 ℃; for 56h;

DOI:10.3390/70400405

upstream raw materials:

N,N'-bisbenzylidene-1,3-diaminopropane

1,3-dibromo-propane

benzylamine

benzyl chloride

Downstream raw materials:

1,3-dibenzyl-2-phenyl-hexahydro-pyrimidine

N,N'-(cyclohexane-1,2-diyl)bis(1-phenylmethanimine)

cis-(1R,2S)-N,N'-dibenzylcyclohexane-1,2-diamine

C₂₅H₂₈N₂O

Refernces

• 1、 Rais, Eduard,Fl?rke, Ulrich,Wilhelm, René. "Synthesis and investigation of new cyclic haloamidinium salts". . p. 667 - 676. Retrieved 2016/07/06.
• 2、 Pardeshi, Kundansingh A.,Malwal, Satish R.,Banerjee, Ankita,Lahiri, Surobhi,Rangarajan, Radha,Chakrapani, Harinath. "Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors". . p. 2694 - 2697. Retrieved 2015/06/08.