(-)-Chloroephedine hydrochloride

Base Information

• Chemical Name: (-)-Chloroephedine hydrochloride
• CAS No.: 27270-80-0
• Molecular Formula: C₁₀H₁₄ClN*ClH
• Molecular Weight: 220.142
• Mol file: 27270-80-0.mol

Synonyms:(-)-Chloroephedine hydrochloride

Chemical Property of (-)-Chloroephedine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-Chloroephedine hydrochloride

There total 8 articles about (-)-Chloroephedine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Novafed (345-78-8) → (-)-Chloroephedine hydrochloride (27270-80-0) + (+)-Chloroephedine hydrochloride (94133-42-3)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/ac00121a011

Reference yield:

ephedrine hydrochloride (50-98-6) → (-)-Chloroephedine hydrochloride (27270-80-0) + (+)-Chloroephedine hydrochloride (94133-42-3)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/ac00121a011

Reference yield:

(+)-(1S,2R)-ephedrine hydrochloride (24221-86-1) → chlorodeoxypseudoephedrine hydrochloride (101859-99-8) + erythro-(1S,2R)-1-chloro-1-phenyl-2-(methylamino)propane hydrochloride (27270-80-0)

Guidance literature:

With thionyl chloride; In chloroform; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/ac00121a011

upstream raw materials:

Novafed

ephedrine hydrochloride

ephedrine

pseudoephedrine

Downstream raw materials:

1-Phenyl-1--2-methylamino-propan

C₁₂H₁₉NO

Refernces

• 1、 Flores-Parra, Angelina,Suarez-Moreno, Patricia,Sanchez-Ruiz, Sonia A.,Tlahuextl, Margarita,Jaen-Gaspar, Javier,Tlahuext, Hugo,Salas-Coronado, Raul,Cruz, Alejandro,Noeth, Heinrich,Contreras, Rosalinda. "Chlorination reactions of ephedrines revisited. Stereochemistry and functional groups effect on the reaction mechanisms". . p. 1661 - 1671. Retrieved 2007/10/03.