Technology Process of C17H16F3N5O3
There total 7 articles about C17H16F3N5O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-methoxy-pyrazine-2-carboxylic acid;
With
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
methanol;
at 0 ℃;
for 0.5h;
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine;
In
methanol;
at 0 - 22 ℃;
for 20h;
DOI:10.1021/jm400225m
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / 50 - 70 °C
2.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 22 - 35 °C / Inert atmosphere
2.2: 2 h / 22 °C / Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C
4.1: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 22 °C
5.1: ethanol / 24 h / 22 - 85 °C / Sealed tube
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / Inert atmosphere
7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.5 h / 0 °C
7.2: 20 h / 0 - 22 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium borohydride; palladium 10% on activated carbon; hydrogen; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; copper(l) chloride; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
2.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 22 - 35 °C / Inert atmosphere
1.2: 2 h / 22 °C / Inert atmosphere
2.1: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C
3.1: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 22 °C
4.1: ethanol / 24 h / 22 - 85 °C / Sealed tube
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / Inert atmosphere
6.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.5 h / 0 °C
6.2: 20 h / 0 - 22 °C
With
hydrogenchloride; lithium borohydride; palladium 10% on activated carbon; hydrogen; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; copper(l) chloride; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
1.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m