Technology Process of methyl 5-chloro-2-[(1,1-dimethyl-2-propyn-1-yl)oxy]benzoate
There total 2 articles about methyl 5-chloro-2-[(1,1-dimethyl-2-propyn-1-yl)oxy]benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-methyl-but-3-yn-2-ol;
With
1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride;
In
acetonitrile;
at -10 - 0 ℃;
for 0.5h;
methyl 5-chloro-2-hydroxybenzoate;
With
1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride;
In
acetonitrile;
at -10 - 0 ℃;
for 74h;
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride;
In
acetonitrile;
at -10 - 0 ℃;
DOI:10.1016/j.bmcl.2011.05.047
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: cesium fluoride; N,N-diethylaniline / 1 - 6 h / 180 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.28 h
3.1: phosphorus tribromide / hexane; dichloromethane / 1 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
5.1: sodium hydroxide; ethanol; water / 1.5 h / 20 °C
5.2: pH 1
6.1: thionyl chloride / dichloromethane / 1.5 - 4.5 h / 20 - 50 °C / Heating / reflux
7.1: triethylamine / dichloromethane / 34 h / 20 °C
With
sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; phosphorus tribromide; potassium carbonate; triethylamine; cesium fluoride; N,N-diethylaniline;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;