2,3,4,5-Tetrahydro-1H-benzo[b]azepine

Base Information

• Chemical Name: 2,3,4,5-Tetrahydro-1H-benzo[b]azepine
• CAS No.: 1701-57-1
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 2933990090
• Mol file: 1701-57-1.mol

Synonyms:2,3,4,5-tetrahydro-1H-1-benzazepine;1H-1-Benzazepine,2,3,4,5-tetrahydro-;

Chemical Property of 2,3,4,5-Tetrahydro-1H-benzo[b]azepine

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 32 °C
• Refractive Index: 1.531
• Boiling Point: 268.9 °C at 760 mmHg
• PKA: 5.22±0.20(Predicted)
• Flash Point: 122.7 °C
• PSA: 12.03000
• Density: 0.981 g/cm³
• LogP: 2.57280
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,5-Tetrahydro-1H-1-benzazepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3,4,5-Tetrahydro-1H-1-benzazepine is a reactant in the synthesis of adamantane derivatives as cannabinoid receptor 2 agonists.

Technology Process of 2,3,4,5-Tetrahydro-1H-benzo[b]azepine

There total 41 articles about 2,3,4,5-Tetrahydro-1H-benzo[b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

Reference yield: 92.0%

1-tetralone oxime (3349-64-2,68253-36-1,100485-58-3) → 2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(00)86234-6

Reference yield: 84.7%

7-Amino-1-(2-(pyrrolidin-1-yl)ethyl)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (1063407-29-3) → 2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1)

Guidance literature:

7-Amino-1-(2-(pyrrolidin-1-yl)ethyl)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 23h;

With sodium hydroxide; water; In tetrahydrofuran;

upstream raw materials:

1-methyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

1-iodo-butane

1-iodo-3-chloro-propane

Downstream raw materials:

4,5,6,7-tetrahydro-azepino[3,2,1-hi]indole-1,2-dione

N-(p-toluoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

2,3,4,5-tetrahydro-1-phenacyl-1H-benzazepine

1,2,3,4-Tetrahydro-1-(4-nitrobenzoyl)-5H-1-benzazepine

Refernces

• 1、 Ahlbrecht,H.,Duebner,E.O.. "-". . p. 1157. Retrieved 1984.
• 2、 Shen, Sida,Picci, Cristina,Ustinova, Kseniya,Benoy, Veronick,Kutil, Zsófia,Zhang, Guiping,Tavares, Maurício T.,Pavlí?ek, Ji?í,Zimprich, Chad A.,Robers, Matthew B.,Van Den Bosch, Ludo,Ba?inka, Cyril,Langley, Brett,Kozikowski, Alan P.. "Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model". . p. 4810 - 4840. Retrieved 2021/05/07.
• 3、 Kaldas, Sherif J.,Kran, Eva,Mück-Lichtenfeld, Christian,Yudin, Andrei K.,Studer, Armido. "Reaction of Vinyl Aziridines with Arynes: Synthesis of Benzazepines and Branched Allyl Fluorides". supporting information. p. 1501 - 1505. Retrieved 2020/02/05.