2-Ethynylpyridine

Base Information

• Chemical Name: 2-Ethynylpyridine
• CAS No.: 1945-84-2
• Molecular Formula: C7H5N
• Molecular Weight: 103.123
• Hs Code.: 29339900
• European Community (EC) Number: 628-748-9
• DSSTox Substance ID: DTXSID40173085
• Nikkaji Number: J208.488K
• Wikidata: Q72477873
• Mol file: 1945-84-2.mol

Synonyms:ethynylpyridine

Chemical Property of 2-Ethynylpyridine

Chemical Property:

• Appearance/Colour: clear dark brown liquid
• Vapor Pressure: 1.94mmHg at 25°C
• Melting Point: 77-78 °C
• Refractive Index: n20/D 1.56(lit.)
• Boiling Point: 170.5 °C at 760 mmHg
• PKA: 2.31±0.12(Predicted)
• Flash Point: 57.5 °C
• PSA: 12.89000
• Density: 1.02 g/cm³
• LogP: 1.06290
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 103.042199164
• Heavy Atom Count: 8
• Complexity: 109

Purity/Quality:

99% ^*data from raw suppliers

2-Ethynylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C#CC1=CC=CC=N1
• Uses: 2-ETHYNYLPYRIDINE is a useful research chemical. 2-Ethynylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Technology Process of 2-Ethynylpyridine

There total 22 articles about 2-Ethynylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(trimethylsilylethynyl)pyridine (86521-05-3) → 2-ethynylpyridine (1945-84-2)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1002/anie.201502390

Reference yield: 90.0%

2-methyl-4-(pyrid-2-yl)but-3-yn-2-ol (29767-97-3) → 2-ethynylpyridine (1945-84-2)

Guidance literature:

With sodium hydroxide; In toluene; Heating;

DOI:10.1055/s-1981-29448

Reference yield: 88.0%

(Z)-2-(2-iodovinyl)pyridine (1092543-20-8) → 2-ethynylpyridine (1945-84-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 6h;

DOI:10.1016/j.tetlet.2008.09.060

upstream raw materials:

2-methyl-4-(pyrid-2-yl)but-3-yn-2-ol

2-(trimethylsilylethynyl)pyridine

2-bromo-pyridine

sodium acetylide

Downstream raw materials:

2-(benzofuran-2-yl)pyridine

2-(2,5-diphenyl-thiophen-3-yl)-pyridine

4-(2-chlorophenyl)-9-methyl-2-[2-(2-pyridinyl)-ethynyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

2-(2-Methoxyethenyl)-pyridine

Refernces

• 1、 Al-Taweel, Samir A.. "Synthesis and characterization of 2,5-bis(2-pyridyl)thiophene". . p. 1041 - 1045. Retrieved 2002.
• 2、 Wang, Dezhi,Chen, Xi,Yang, Hua,Zhong, Daokun,Liu, Boao,Yang, Xiaolong,Yue, Ling,Zhou, Guijiang,Ma, Miaofeng,Wu, Zhaoxin. "The synthesis of cyclometalated platinum(ii) complexes with benzoaryl-pyridines as C^N ligands for investigating their photophysical, electrochemical and electroluminescent properties". supporting information. p. 15633 - 15645. Retrieved 2020/11/24.