m-tetrahydropyran-2-yloxyaminobenzene

Base Information

• Chemical Name: m-tetrahydropyran-2-yloxyaminobenzene
• CAS No.: 147985-36-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 147985-36-2.mol

Synonyms:m-tetrahydropyran-2-yloxyaminobenzene

Chemical Property of m-tetrahydropyran-2-yloxyaminobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of m-tetrahydropyran-2-yloxyaminobenzene

There total 3 articles about m-tetrahydropyran-2-yloxyaminobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(2-tetrahydropyranyloxy)nitrobenzene (28659-20-3) → m-tetrahydropyran-2-yloxyaminobenzene (147985-36-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h; under 2585.81 Torr;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → m-tetrahydropyran-2-yloxyaminobenzene (147985-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / TsOH*H₂O / benzene / 1 h / 50 °C

2: hydrogen / 10 percent Pd/C / ethanol / 4 h / 20 °C / 760 Torr

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; benzene;

DOI:10.3987/com-02-s27

Reference yield:

meta-nitrophenol (554-84-7) → m-tetrahydropyran-2-yloxyaminobenzene (147985-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / TsOH*H₂O / benzene / 1 h / 50 °C

2: hydrogen / 10 percent Pd/C / ethanol / 4 h / 20 °C / 760 Torr

With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; benzene;

DOI:10.3987/com-02-s27

upstream raw materials:

3-(2-tetrahydropyranyloxy)nitrobenzene

3,4-dihydro-2H-pyran

meta-nitrophenol

Downstream raw materials:

m-tetrahydropyran-2-yloxy-N-(benzyloxycarbonyl)aminobenzene

C₁₉H₁₉N₃O₃

m-Hydroxyaniline

1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one

Refernces

• 1、 Sekizaki, Haruo,Itoh, Kunihiko,Toyota, Eiko,Tanizawa, Kazutaka. "A facile synthesis of benzofuran derivatives: A useful synthon for preparation of trypsin inhibitor". . p. 237 - 243. Retrieved 2007/10/03.