Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

Base Information

• Chemical Name: Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate
• CAS No.: 252022-31-4
• Molecular Formula: C₁₇H₂₃ClO₄
• Molecular Weight: 326.82
• Mol file: 252022-31-4.mol

Synonyms:Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

Chemical Property of Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate

There total 8 articles about Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyric acid (169032-14-8) → Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate (252022-31-4)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenylpropionic acid (826-55-1) → Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate (252022-31-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 99 percent / LiAlH₄ / diethyl ether

2: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

3: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

4: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

5: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

6: 89 percent / Jones reagent / acetone / 0 °C

7: 92 percent / diethyl ether / 0 °C

With methanol; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; jones reagent; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; diethyl ether; acetone; benzene; 1: Reduction / 2: Acetylation / 3: Acylation / 4: acetalisation / 5: deacetylation / 6: Oxidation / 7: Methylation;

DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

2-methyl-2-phenyl-propan-1-ol (2173-69-5) → Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate (252022-31-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

2: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

3: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

5: 89 percent / Jones reagent / acetone / 0 °C

6: 92 percent / diethyl ether / 0 °C

With methanol; sodium hydroxide; aluminium trichloride; jones reagent; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In carbon disulfide; diethyl ether; acetone; benzene; 1: Acetylation / 2: Acylation / 3: acetalisation / 4: deacetylation / 5: Oxidation / 6: Methylation;

DOI:10.1016/S0014-827X(99)00070-1

upstream raw materials:

diazomethane

2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyric acid

2-methyl-2-phenylpropionic acid

2-methyl-2-phenyl-propan-1-ol

Downstream raw materials:

Methyl 2-[4-(1-hydroxy-4-chlorobutyl)phenyl]isobutyrate

fexofenadine methyl ester

fexofenadine

2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester

Refernces