2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester

Base Information

• Chemical Name: 2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester
• CAS No.: 180133-20-4
• Molecular Formula: C₁₇H₂₃NO₆
• Molecular Weight: 337.373
• Mol file: 180133-20-4.mol

Synonyms:2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester

Chemical Property of 2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester

There total 1 articles about 2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,6-dimethyl-4-heptanol (108-82-7) + 2-nitroterephthalic acid (610-29-7) → 2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester (180133-20-4) + 2-Nitro-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester (180133-12-4)

Guidance literature:

With sulfuric acid; In toluene; for 7.5h; Heating;

DOI:10.1021/ja9539857

Reference yield:

2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester (180133-20-4) → 2-{2-[2-Amino-4-(1-isobutyl-3-methyl-butoxycarbonyl)-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester (180133-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 30 h / Ambient temperature

2: 54 percent / pyridine / CH₂Cl₂ / Ambient temperature

3: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / Ambient temperature

With pyridine; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja9539857

Reference yield:

2-nitroterephthalic acid 4-(2,6-dimethyl-4-heptyl) ester (180133-20-4) → 2-{2-[2-(2-Amino-4-methoxycarbonyl-benzoylamino)-4-(1-isobutyl-3-methyl-butoxycarbonyl)-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester (180133-19-1)

Guidance literature:

Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 30 h / Ambient temperature

2: 54 percent / pyridine / CH₂Cl₂ / Ambient temperature

3: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / Ambient temperature

4: 60 percent / pyridine / CH₂Cl₂ / Ambient temperature

5: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / Ambient temperature

With pyridine; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja9539857

upstream raw materials:

2,6-dimethyl-4-heptanol

2-nitroterephthalic acid

Downstream raw materials:

2-{2-[2-Amino-4-(1-isobutyl-3-methyl-butoxycarbonyl)-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester

2-{2-[4-(1-Isobutyl-3-methyl-butoxycarbonyl)-2-nitro-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester

2-{2-[2-(2-Amino-4-methoxycarbonyl-benzoylamino)-4-(1-isobutyl-3-methyl-butoxycarbonyl)-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester

2-{2-[4-(1-Isobutyl-3-methyl-butoxycarbonyl)-2-(4-methoxycarbonyl-2-nitro-benzoylamino)-benzoylamino]-4-methoxycarbonyl-benzoylamino}-terephthalic acid bis-(1-isobutyl-3-methyl-butyl) ester

Refernces